Synthesis of pyridine derivatives as potential antagonists of chemokine receptor type 4

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Abstract: A series of pyridine derivatives were synthesized as potential inhibitors of chemokine receptor type 4. This chemokine receptor has been linked to various disease pathways including HIV-1 proliferation, autoimmune disorders, inflammatory diseases, and cancer metastasis. The compounds were tested for activity using an affinity binding assay and an assay that tests the ability to inhibit cell invasion. Two hit compounds (2b and 2j) have been identified for further evaluation that inhibit cell invasion by at least 50% and have an effective concentration of less than 100 nm in the binding affinity assay. The structures of the synthesized compounds were confirmed by spectral data.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Synthesis of pyridine derivatives as potential antagonists of chemokine receptor type 4 ; volume:20 ; number:3 ; year:2014 ; pages:149-153 ; extent:5
Heterocyclic communications ; 20, Heft 3 (2014), 149-153 (gesamt 5)

Creator: Mooring, Suazette Reid
Gaines, Theresa
Liang, Zhongxing
Shim, Hyunsuk

DOI: 10.1515/hc-2014-0041

URN: urn:nbn:de:101:1-2501130606575.940365615223

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.20252025, 11:25 AM CEST

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Mooring, Suazette Reid
Gaines, Theresa
Liang, Zhongxing
Shim, Hyunsuk

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Synthesis of pyridine derivatives as potential antagonists of chemokine receptor type 4

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Other Objects (12)

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