Expressions of Type I–III Interferons in Sjögren’s Syndrome and Non-Sjögren’s Dry Eye

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Abstract: Introduction: Systemic implications create a critical need for identification of dry eye patients with Sjögren syndrome (SS). Herein, we aimed to determine expressions of type I–III interferons (IFNs) in dry eye patients with or without underlying SS and their differential diagnosis. Methods: A prospective, observational, case-control study was performed on 140 dry eye patients among which 78 patients were diagnosed with SS. Clinical evaluations included ELISA detections of serum type I IFN (IFN-α and IFN-β, type II IFN (IFN-γ), and type III IFN (IFN-λ1/IL-29, IFN-λ2/IL-28, and IFN-λ3/IL-28B), as well as reporter cell assay for serum type I IFN activity. Results: The serum levels of IFN-α and IFN-β were notably higher in dry eye patients with SS than those without underlying SS (p < 0.0001). The functional assay for serum type I IFN activity showed the mean summed scores in dry eye patients with SS were remarkably increased compared to those without underlying SS (p < 0.0001). The serum levels of IFN-γ and IFN-λ1/IL-29 seemed higher in dry eye patients with SS than those without underlying SS (p < 0.0001). The serum levels of type I IFN (IFN-α combined with IFN-β), type II IFN (IFN-γ level), and type III IFN (IFN-λ1/IL-29) used as a test to predict underlying SS among dry eye patients produced an area under the curve of 0.86, 0.73, and 0.94, respectively. Conclusion: Serum levels of type I–III IFNs, especially IFN-α, IFN-β, and IFN-λ1/IL-29, may serve as a useful biomarker for identification of SS dry eye from non-SS dry eye.

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch

Erschienen in
Expressions of Type I–III Interferons in Sjögren’s Syndrome and Non-Sjögren’s Dry Eye ; volume:67 ; number:1 ; year:2024 ; pages:470-477 ; extent:8
Ophthalmic research ; 67, Heft 1 (2024), 470-477 (gesamt 8)

Urheber
Su, Nan
Jiang, Lei
Wang, Yanpeng
Dong, Yanping
Yong, Yanjuan
Yang, Kan
Gao, Shixiong

DOI
10.1159/000540295
URN
urn:nbn:de:101:1-2412260227357.054293700848
Rechteinformation
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
15.08.2025, 07:23 MESZ

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Beteiligte

  • Su, Nan
  • Jiang, Lei
  • Wang, Yanpeng
  • Dong, Yanping
  • Yong, Yanjuan
  • Yang, Kan
  • Gao, Shixiong

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