Development of a photoactivatable protein phosphatase-1-disrupting peptide
Abstract: We describe here the development of a photoreleasable version of a protein phosphatase-1 (PP1)-disrupting peptide (PDP-Nal) that triggers protein phosphatase-1 activity. PDP-Nal is a 23 mer that binds to PP1 through several interactions. It was photocaged on a tyrosine residue, which required the exchange of phenylalanine in PDP-Nal to tyrosine in order to disrupt the most important binding interface. This PDP-caged can be light-controlled in live cells
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Anmerkungen
-
The journal of organic chemistry. - 85, 3 (2020) , 1712-1717, ISSN: 1520-6904
- Ereignis
-
Veröffentlichung
- (wo)
-
Freiburg
- (wer)
-
Universität
- (wann)
-
2021
- Urheber
- Beteiligte Personen und Organisationen
-
Abteilung Integrative Signalforschung
- DOI
-
10.1021/acs.joc.9b02548
- URN
-
urn:nbn:de:bsz:25-freidok-2211010
- Rechteinformation
-
Kein Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
- 15.08.2025, 07:27 MESZ
Datenpartner
Dieses Objekt wird bereitgestellt von:
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Trębacz, Małgorzata
- Wang, Yansong
- Makotta, Leslie
- Henschke, Lars
- Köhn, Maja
- Abteilung Integrative Signalforschung
- Universität
Entstanden
- 2021
Ähnliche Objekte (12)
Short peptide pharmacophores developed from protein phosphatase-1 disrupting peptides (PDPs)
Development of a peptide that selectively activates protein phosphatase-1 in living cells
Identification of an H-Ras nanocluster disrupting peptide
An enhancer peptide for membrane-disrupting antimicrobial peptides
Prediction and verification of novel peptide targets of protein tyrosine phosphatase 1B
Development of Specific Activators and Inhibitors for Protein Phosphatase 1
Chromenopyrazole−Peptide Conjugates as Small‐Molecule Based Inhibitors Disrupting the Protein−RNA Interaction of LIN28‐ let‐7
Investigations of Protein Tyrosine Phosphatase Functions
Aminosäuren, Peptide, Proteine
Endocrine disrupting compounds exposure and testis development in mammals
Disrupting concrete construction
Membrane targeting with palmitoylated lysine added to PP1‐disrupting peptide induces PP1‐independent signaling
Short peptide pharmacophores developed from protein phosphatase-1 disrupting peptides (PDPs)
Development of a peptide that selectively activates protein phosphatase-1 in living cells
Identification of an H-Ras nanocluster disrupting peptide
An enhancer peptide for membrane-disrupting antimicrobial peptides
Prediction and verification of novel peptide targets of protein tyrosine phosphatase 1B
Development of Specific Activators and Inhibitors for Protein Phosphatase 1
Chromenopyrazole−Peptide Conjugates as Small‐Molecule Based Inhibitors Disrupting the Protein−RNA Interaction of LIN28‐ let‐7
Investigations of Protein Tyrosine Phosphatase Functions
Aminosäuren, Peptide, Proteine
Endocrine disrupting compounds exposure and testis development in mammals
Disrupting concrete construction
Membrane targeting with palmitoylated lysine added to PP1‐disrupting peptide induces PP1‐independent signaling
Short peptide pharmacophores developed from protein phosphatase-1 disrupting peptides (PDPs)
Development of a peptide that selectively activates protein phosphatase-1 in living cells
Identification of an H-Ras nanocluster disrupting peptide
An enhancer peptide for membrane-disrupting antimicrobial peptides
Prediction and verification of novel peptide targets of protein tyrosine phosphatase 1B
Development of Specific Activators and Inhibitors for Protein Phosphatase 1
Chromenopyrazole−Peptide Conjugates as Small‐Molecule Based Inhibitors Disrupting the Protein−RNA Interaction of LIN28‐ let‐7
Investigations of Protein Tyrosine Phosphatase Functions
Aminosäuren, Peptide, Proteine
Endocrine disrupting compounds exposure and testis development in mammals
Disrupting concrete construction