Spatial and Single‐Cell Transcriptomics Unraveled Spatial Evolution of Papillary Thyroid Cancer
Abstract: Recurrence and metastasis are the major issues for papillary thyroid cancer (PTC). Current morphological and molecular classification systems are not satisfied for PTC diagnosis due to lacking variant‐specific morphological criteria and high signal‐to‐noise in mutation‐based diagnosis, respectively. Importantly, intratumor heterogeneity is largely lost in current molecular classification system, which can be resolved by single cell RNA sequencing (scRNA‐seq). However, scRNA‐seq loses spatial information and morphological features. Herein, scRNA‐seq is integrated and spatially‐resolved transcriptomics (SRT) to elaborate the mechanisms underlying the spatial heterogeneity, malignancy and metastasis of PTCs by associating transcriptome and local morphology. This results demonstrated that PTC cells evolved with multiple routes, driven by the enhanced aerobic metabolism and the suppressed mRNA translation and protein synthesis and the involvement of cell–cell interaction. Two curated malignant and metastatic footprints can discriminate PTC cells from normal thyrocytes. Ferroptosis resistance contributed to PTC evolution. This results will advance the knowledge of intratumor spatial heterogeneity and evolution of PTCs at spatial and single‐cell levels, and propose better diagnostic strategy.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Spatial and Single‐Cell Transcriptomics Unraveled Spatial Evolution of Papillary Thyroid Cancer ; day:14 ; month:11 ; year:2024 ; extent:13
Advanced science ; (14.11.2024) (gesamt 13)
- Creator
-
Zheng, Guangzhe
Chen, Shaobo
Ma, Wanqi
Wang, Quanshu
Sun, Li
Zhang, Changwen
Chen, Ge
Zhang, Shuping
Chen, Shuguang
- DOI
-
10.1002/advs.202404491
- URN
-
urn:nbn:de:101:1-2411141356390.599021736286
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
- 15.08.2025, 7:24 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Zheng, Guangzhe
- Chen, Shaobo
- Ma, Wanqi
- Wang, Quanshu
- Sun, Li
- Zhang, Changwen
- Chen, Ge
- Zhang, Shuping
- Chen, Shuguang
Other Objects (12)
Urban Social Assistance in China: Transnational Diffusion and National Interpretation
Social media usage and students’ social anxiety, loneliness and well-being: does digital mindfulness-based intervention effectively work?
Urban Social Assistance in China: Transnational Diffusion and National Interpretation
Analysis of oxide scale thickness and pores position of HCM12A steel in supercritical water
Single-cell spatial explorer: easy exploration of spatial and multimodal transcriptomics
Integrating Spatial Information in Single-Cell Transcriptomics Analysis
Models for Interest Rates and Interest Rate Derivatives
Bacillus cereus cytotoxin K triggers gasdermin D-dependent pyroptosis
Identification and characterization of immune-related lncRNAs and lncRNA-miRNA-mRNA networks of Paralichthys olivaceus involved in Vibrio anguillarum infection
Single-cell and spatial transcriptomics of the bone marrow
Spatial transcriptomics deconvolution at single-cell resolution using Redeconve
Integrating spatial and single-cell transcriptomics data using deep generative models with SpatialScope
Urban Social Assistance in China: Transnational Diffusion and National Interpretation
Social media usage and students’ social anxiety, loneliness and well-being: does digital mindfulness-based intervention effectively work?
Urban Social Assistance in China: Transnational Diffusion and National Interpretation
Analysis of oxide scale thickness and pores position of HCM12A steel in supercritical water
Single-cell spatial explorer: easy exploration of spatial and multimodal transcriptomics
Integrating Spatial Information in Single-Cell Transcriptomics Analysis
Models for Interest Rates and Interest Rate Derivatives
Bacillus cereus cytotoxin K triggers gasdermin D-dependent pyroptosis
Identification and characterization of immune-related lncRNAs and lncRNA-miRNA-mRNA networks of Paralichthys olivaceus involved in Vibrio anguillarum infection
Single-cell and spatial transcriptomics of the bone marrow
Spatial transcriptomics deconvolution at single-cell resolution using Redeconve
Integrating spatial and single-cell transcriptomics data using deep generative models with SpatialScope
Urban Social Assistance in China: Transnational Diffusion and National Interpretation
Social media usage and students’ social anxiety, loneliness and well-being: does digital mindfulness-based intervention effectively work?
Urban Social Assistance in China: Transnational Diffusion and National Interpretation
Analysis of oxide scale thickness and pores position of HCM12A steel in supercritical water
Single-cell spatial explorer: easy exploration of spatial and multimodal transcriptomics
Integrating Spatial Information in Single-Cell Transcriptomics Analysis
Models for Interest Rates and Interest Rate Derivatives
Bacillus cereus cytotoxin K triggers gasdermin D-dependent pyroptosis
Identification and characterization of immune-related lncRNAs and lncRNA-miRNA-mRNA networks of Paralichthys olivaceus involved in Vibrio anguillarum infection
Single-cell and spatial transcriptomics of the bone marrow
Spatial transcriptomics deconvolution at single-cell resolution using Redeconve