Molecular mechanisms of tumor immunomodulation in the microenvironment of colorectal cancer

Abstract: Colorectal cancer remains one of the most important health challenges in our society. The development of cancer immunotherapies has fostered the need to better understand the anti-tumor immune mechanisms at play in the tumor microenvironment and the strategies by which the tumor escapes them. In this review, we provide an overview of the molecular interactions that regulate tumor inflammation. We particularly discuss immunomodulatory cell-cell interactions, cell-soluble factor interactions, cell-extracellular matrix interactions and cell-microbiome interactions. While doing so, we highlight relevant examples of tumor immunomodulation in colorectal cancer

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• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch
• Notes: International journal of molecular sciences. - 23, 5 (2022) , 2782, ISSN: 1422-0067

Contributors, Places and Time

• Event: Veröffentlichung
• (where): Freiburg
• (who): Universität
• (when): 2022
• Creator: Plundrich, Dorothea ; Chikhladze, Sophia ; Fichtner-Feigl, Stefan ; Feuerstein, Reinhild ; Briquez, Priscilla S.

Further information

• DOI: 10.3390/ijms23052782
• URN: urn:nbn:de:bsz:25-freidok-2256252
• Rights: Kein Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.