Efficient synthesis of 3-(bromomethyl)-5-methylpyridine hydrobromide

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Abstract: 5-Methyl-3-(bromomethyl) pyridine is the key intermediate in the synthesis of rupatadine. In this article, a new preparation of 5-methyl-3-(bromomethyl) pyridine hydrobromide is reported, which used 5-methylnicotinic acid as the starting material, with a 65.9% overall yield. This method has the merits of being simple, efficient and environmentally friendly.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Efficient synthesis of 3-(bromomethyl)-5-methylpyridine hydrobromide ; volume:21 ; number:4 ; year:2015 ; pages:203-205 ; extent:3
Heterocyclic communications ; 21, Heft 4 (2015), 203-205 (gesamt 3)

Creator: Guo, Jianyu
Lu, Yan
Wang, Jin

DOI: 10.1515/hc-2015-0107

URN: urn:nbn:de:101:1-2501130621106.272444204716

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:20 AM CEST

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Guo, Jianyu
Lu, Yan
Wang, Jin

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Efficient synthesis of 3-(bromomethyl)-5-methylpyridine hydrobromide

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