Septin dynamics and organization in mammalian cells
Abstract: Septins are involved in many important cellular processes, and septin dysfunction has been implicated in various pathologies, such as cancer. Like other components of the cytoskeleton -F-actin, microtubules, and intermediate filaments-septins can self-assemble into filaments and higher-order structures. These non-polar filaments are assembled from complex and variable multimeric building blocks. Septins exhibit a distinct preference for interacting with actin and microtubule structures, particularly at the interface with cellular membrane. Although they are crucial for many vital cellular functions and are frequently observed at prominent cellular structures like stress fibers, cilia, and neuronal processes, our understanding of the regulation of septin filament dynamics and the organized assembly of higher-order structures remains limited. However, recent insights into the architecture of septin filaments, the structure of crucial septin domains, and their interactions with other cellular components (F-actin, microtubules, membranes) and regulatory proteins may now pave the way for rapid progress
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Anmerkungen
-
Current opinion in cell biology. - 91 (2024) , 102442, ISSN: 1879-0410
- Ereignis
-
Veröffentlichung
- (wo)
-
Freiburg
- (wer)
-
Universität
- (wann)
-
2024
- Urheber
- DOI
-
10.1016/j.ceb.2024.102442
- URN
-
urn:nbn:de:bsz:25-freidok-2589441
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
- 15.08.2025, 05:38 UTC
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Schampera, Janik Niklas
- Schwan, Carsten
- Universität
Entstanden
- 2024
Ähnliche Objekte (12)
The mammalian septin interactome
Requirements for mammalian promoters to decode transcription factor dynamics
The bacterial lectin LecA from P. aeruginosa alters membrane organization by dispersing ordered domains
Multichromatic control of signaling pathways in mammalian cells
Single-cell dispensing for isolation and analysis of individual mammalian and microbial cells
Discovering immunoreceptor coupling and organization motifs
Organization of antibiotic stewardship in Europe: the way to go
Dynamic organization of chromosomes in the mammalian cell nucleus
Dynamic organization of chromosomes in the mammalian cell nucleus
Optogenetic control of the mitochondrial protein import in mammalian cells
Deciphering small-scale seasonal surface dynamics of rock glaciers in the Central European Alps using DInSAR time series
Synthetic extracellular matrix for controlled endothelial cell organization : = Synthetische Extrazelluläre Matrix für die Organisation von Endothelzellen
The mammalian septin interactome
Requirements for mammalian promoters to decode transcription factor dynamics
The bacterial lectin LecA from P. aeruginosa alters membrane organization by dispersing ordered domains
Multichromatic control of signaling pathways in mammalian cells
Single-cell dispensing for isolation and analysis of individual mammalian and microbial cells
Discovering immunoreceptor coupling and organization motifs
Organization of antibiotic stewardship in Europe: the way to go
Dynamic organization of chromosomes in the mammalian cell nucleus
Dynamic organization of chromosomes in the mammalian cell nucleus
Optogenetic control of the mitochondrial protein import in mammalian cells
Deciphering small-scale seasonal surface dynamics of rock glaciers in the Central European Alps using DInSAR time series
Synthetic extracellular matrix for controlled endothelial cell organization : = Synthetische Extrazelluläre Matrix für die Organisation von Endothelzellen
The mammalian septin interactome
Requirements for mammalian promoters to decode transcription factor dynamics
The bacterial lectin LecA from P. aeruginosa alters membrane organization by dispersing ordered domains
Multichromatic control of signaling pathways in mammalian cells
Single-cell dispensing for isolation and analysis of individual mammalian and microbial cells
Discovering immunoreceptor coupling and organization motifs
Organization of antibiotic stewardship in Europe: the way to go
Dynamic organization of chromosomes in the mammalian cell nucleus
Dynamic organization of chromosomes in the mammalian cell nucleus
Optogenetic control of the mitochondrial protein import in mammalian cells
Deciphering small-scale seasonal surface dynamics of rock glaciers in the Central European Alps using DInSAR time series