Long-term recording performance and biocompatibility of chronically implanted cylindrically-shaped, polymer-based neural interfaces

Abstract: Stereo-electroencephalography depth electrodes, regularly implanted into drug-resistant patients with focal epilepsy to localize the epileptic focus, have a low channel count (6–12 macro- or microelectrodes), limited spatial resolution (0.5–1 cm) and large contact area of the recording sites (~mm2). Thus, they are not suited for high-density local field potential and multiunit recordings. In this paper, we evaluated the long-term electrophysiological recording performance and histocompatibility of a neural interface consisting of 32 microelectrodes providing a physical shape similar to clinical devices. The cylindrically-shaped depth probes made of polyimide (PI) were chronically implanted for 13 weeks into the brain of rats, while cortical or thalamic activity (local field potentials, single-unit and multi-unit activity) was recorded regularly to monitor the temporal change of several features of the electrophysiological performance. To examine the tissue reaction around the probe, neuron-selective and astroglia-selective immunostaining methods were applied. Stable single-unit and multi-unit activity were recorded for several weeks with the implanted depth probes and a weak or moderate tissue reaction was found around the probe track. Our data on biocompatibility presented here and in vivo experiments in non-human primates provide a strong indication that this type of neural probe can be applied in stereo-electroencephalography recordings of up to 2 weeks in humans targeting the localization of epileptic foci providing an increased spatial resolution and the ability to monitor local field potentials and neuronal spiking activity

Objekt anzeigen

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch
• Anmerkungen: Biomedical engineering. - 63, 3 (2018) , 301-315, ISSN: 1862-278X

Klassifikation und Themen

• Schlagwort: MHC

Beteiligte, Orts- und Zeitangaben

• Ereignis: Veröffentlichung
• (wo): Freiburg
• (wer): Universität
• (wann): 2019
• Urheber: Fiáth, Richárd ; Hofer, Katharina T. ; Csikós, Vivien ; Horváth, Domonkos ; Nánási, Tibor ; Tóth, Kinga ; Pothof, Frederick ; Böhler, Christian ; Asplund, Maria ; Ruther, Patrick ; Ulbert, István

Weitere Informationen

• DOI: 10.1515/bmt-2017-0154
• URN: urn:nbn:de:bsz:25-freidok-1439175
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.