Decreased Salivary Uptake of (14C)-Xylitol after a Four-week Xylitol Chewing Gum Regimen

Purpose: The aims were to evaluate a simple method to disclose a microbial shift in saliva and to investigate the short- and long-term effects of daily use of xylitol-containing chewing gums on mutans streptococci (MS) and [14C]-xylitol uptake in saliva. Materials and Methods: In a pilot set-up, saliva samples were collected from 15 healthy adults and the uptake of xylitol was compared with a specific assay determining xylitol-sensitive MS. The main study consisted of 109 schoolchildren (mean age 9.9 years) who volunteered after informed consent. The children were randomly allocated to a test or control group. The control group was given two pellets containing sorbitol and maltitol 3 times daily for 4 weeks and the test group received identical pellets with xylitol as single sweetener (total dose 6.2 g/day). Saliva samples were collected at baseline, after 4 weeks and 6 months after the intervention. The outcome measures were MS and total viable counts, proportion of MS and salivary uptake of [14C]-xylitol. Results: The pilot study disclosed a fair positive correlation (p < 0.05) between the assays. The proportions of MS and salivary xylitol uptake decreased significantly in the xylitol group by 60% and 30% respectively after 4 weeks compared to baseline which was in contrast to the sorbitol/maltitol group (p < 0.05). Six months after the intervention, the outcome measures did not differ significantly from baseline in any of the groups. Conclusion: A relatively high daily dose of xylitol could alter salivary microbial composition during the intervention period but no long-term impact was observed.

Objekt anzeigen

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Decreased Salivary Uptake of (14C)-Xylitol after a Four-week Xylitol Chewing Gum Regimen ; volume:5 ; number:4 ; year:2007 ; pages:313-319 ; Oral health & preventive dentistry ; 5, Heft 4 (2007), 313-319

Beteiligte, Orts- und Zeitangaben

• Urheber: Holgerson, Pernilla Lif ; Sjöström, Inger ; Twetman, Svante

Weitere Informationen

• DOI: 10.3290/j.ohpd.a12801
• URN: urn:nbn:de:101:1-2023052015035568414859
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.