Catalytic Asymmetric Conjugate Reduction
Abstract: Enantioselective reduction reactions are privileged transformations for the construction of trisubstituted stereogenic centers. While these include established synthetic strategies, such as asymmetric hydrogenation, methods based on the enantioselective addition of hydridic reagents to electrophilic prochiral substrates have also gained importance. In this context, the asymmetric conjugate reduction (ACR) of α,β‐unsaturated compounds has become a convenient approach for the synthesis of chiral compounds with trisubstituted stereocenters in α‐, β‐, or γ‐position to electron‐withdrawing functional groups. Because such activating groups are diverse and amenable of further derivatizations, ACRs provide a general and powerful synthetic entry towards a variety of valuable chiral building blocks. This Review provides a comprehensive collection of catalytic ACR methods involving transition‐metal, organic, and enzymatic catalysis since its first versions dating back to the late 1970s.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Catalytic Asymmetric Conjugate Reduction ; day:27 ; month:02 ; year:2023 ; extent:34
Angewandte Chemie ; (27.02.2023) (gesamt 34)
- Urheber
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Lonardi, Giovanni
Parolin, Riccardo
Licini, Giulia
Orlandi, Manuel
- DOI
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10.1002/ange.202216649
- URN
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urn:nbn:de:101:1-2023022814195492844073
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
- 14.08.2025, 10:44 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Lonardi, Giovanni
- Parolin, Riccardo
- Licini, Giulia
- Orlandi, Manuel
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