Synthesis of Multifunctional Protein‐Polymer Conjugates via Oxygen‐tolerant, Aqueous Copper‐Mediated Polymerization, and Bioorthogonal Click Chemistry
Abstract: Oxygen‐tolerant, aqueous copper‐mediated polymerization approaches are combined with click chemistry in either a sequential or a simultaneous manner, to enable the synthesis of multifunctional protein‐polymer conjugates. Propargyl acrylate (PgA) and propargyl methacrylate (PgMA) grafting from a bovine serum albumin (BSA) macroinitiator is thoroughly optimized to synthesize chemically addressable BSA‐poly (propargyl acrylate) and BSA‐poly (propargyl methacrylate) respectively. The produced multifunctional bioconjugates bear pendant terminal 1‐alkynes which can be readily post‐functionalized via both [3+2] Huisgen cycloaddition and thiol‐yne click chemistry under mild reaction conditions. Simultaneous oxygen‐tolerant, aqueous copper‐catalyzed polymerization, and click chemistry mediate the in situ multiple chemical tailoring of biomacromolecules in excellent yields.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Synthesis of Multifunctional Protein‐Polymer Conjugates via Oxygen‐tolerant, Aqueous Copper‐Mediated Polymerization, and Bioorthogonal Click Chemistry ; day:25 ; month:04 ; year:2023 ; extent:7
Macromolecular rapid communications ; (25.04.2023) (gesamt 7)
- Creator
-
Voutyritsa, Errika
Gryparis, Charis
Theodorou, Alexis
Velonia, Kelly
- DOI
-
10.1002/marc.202200976
- URN
-
urn:nbn:de:101:1-2023042615275578004089
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
14.08.2025, 10:57 AM CEST
Data provider
This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Voutyritsa, Errika
- Gryparis, Charis
- Theodorou, Alexis
- Velonia, Kelly
Other Objects (12)
A Bioorthogonal Click Chemistry Toolbox for Targeted Synthesis of Branched and Well-Defined Protein–Protein Conjugates
A Bioorthogonal Click Chemistry Toolbox for Targeted Synthesis of Branched and Well‐Defined Protein–Protein Conjugates †
A Bioorthogonal Click Chemistry Toolbox for Targeted Synthesis of Branched and Well‐Defined Protein–Protein Conjugates †
Improving bioorthogonal protein ubiquitylation by click reaction
Bioorthogonal Click of Colloidal Gold Nanoparticles to Antibodies In vivo
Bioorthogonal metal-free click-ligation of cRGD-pentapeptide to alginate
Bioorthogonal “Click-and-Release” of Iminosydnones to Give Water-Stable Isocyanates
Bioorthogonal click chemistry for fluorescence imaging of choline phospholipids in plants
Multifunctional Clickable Reagents for Rapid Bioorthogonal Astatination and Radio‐Crosslinking
Development of Biocompatible Cu (I)‐Microdevices for Bioorthogonal Uncaging and Click Reactions
Photoactivatable Fluorogenic Labeling via Turn‐On “Click‐Like” Nitroso‐Diene Bioorthogonal Reaction
Development of bioorthogonal synthetic strategies towards hybrid macromolecular conjugates with tailored properties
A Bioorthogonal Click Chemistry Toolbox for Targeted Synthesis of Branched and Well-Defined Protein–Protein Conjugates
A Bioorthogonal Click Chemistry Toolbox for Targeted Synthesis of Branched and Well‐Defined Protein–Protein Conjugates †
A Bioorthogonal Click Chemistry Toolbox for Targeted Synthesis of Branched and Well‐Defined Protein–Protein Conjugates †
Improving bioorthogonal protein ubiquitylation by click reaction
Bioorthogonal Click of Colloidal Gold Nanoparticles to Antibodies In vivo
Bioorthogonal metal-free click-ligation of cRGD-pentapeptide to alginate
Bioorthogonal “Click-and-Release” of Iminosydnones to Give Water-Stable Isocyanates
Bioorthogonal click chemistry for fluorescence imaging of choline phospholipids in plants
Multifunctional Clickable Reagents for Rapid Bioorthogonal Astatination and Radio‐Crosslinking
Development of Biocompatible Cu (I)‐Microdevices for Bioorthogonal Uncaging and Click Reactions
Photoactivatable Fluorogenic Labeling via Turn‐On “Click‐Like” Nitroso‐Diene Bioorthogonal Reaction
Development of bioorthogonal synthetic strategies towards hybrid macromolecular conjugates with tailored properties
A Bioorthogonal Click Chemistry Toolbox for Targeted Synthesis of Branched and Well-Defined Protein–Protein Conjugates
A Bioorthogonal Click Chemistry Toolbox for Targeted Synthesis of Branched and Well‐Defined Protein–Protein Conjugates †
A Bioorthogonal Click Chemistry Toolbox for Targeted Synthesis of Branched and Well‐Defined Protein–Protein Conjugates †
Improving bioorthogonal protein ubiquitylation by click reaction
Bioorthogonal Click of Colloidal Gold Nanoparticles to Antibodies In vivo
Bioorthogonal metal-free click-ligation of cRGD-pentapeptide to alginate
Bioorthogonal “Click-and-Release” of Iminosydnones to Give Water-Stable Isocyanates
Bioorthogonal click chemistry for fluorescence imaging of choline phospholipids in plants
Multifunctional Clickable Reagents for Rapid Bioorthogonal Astatination and Radio‐Crosslinking
Development of Biocompatible Cu (I)‐Microdevices for Bioorthogonal Uncaging and Click Reactions
Photoactivatable Fluorogenic Labeling via Turn‐On “Click‐Like” Nitroso‐Diene Bioorthogonal Reaction