Pacemakers and methylprednisolone pulse therapy in immune-related myocarditis concomitant with complete heart block
Abstract: Immune-related cardiotoxicities are uncommon but potentially fatal. The study aims to evaluate the value of pacemakers and methylprednisolone pulse therapy (MPPT) to patients with immune-related myocarditis concomitant with complete heart block (CHB). We first reviewed medical records of three patients with immune-related myocarditis concomitant with CHB. For the pooled analysis, we searched related cases with immune-related myocarditis in the PubMed database and screened the patients. Clinical characteristics, management, and outcomes were summarized. Our three patients developed immune-related myocarditis concomitant with CHB about 2 weeks after receiving pembrolizumab, and were successfully treated with pacemaker implantation and high-dose steroids (two received MPPT). In the pooled analysis, 21 cases were eligible with an overall fatality rate of 52%. Patients with pacemakers had a fatality rate of 38%, significantly lower than patients without them (38% vs 100%; p = 0.035), particularly the MPPT subgroup (25% vs 100%; p = 0.019). All five patients without pacemakers expired. Among patients with pacemakers, MPPT patients tended to have an inferior rate compared with non-MPPT patients. Timely pacemaker implantation played a crucial role in improving the outcomes of patients with immune-related myocarditis concomitant with CHB. Patients receiving MPPT appeared to have a better prognosis. Additionally, multidisciplinary consultation should be recommended for better management.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Pacemakers and methylprednisolone pulse therapy in immune-related myocarditis concomitant with complete heart block ; volume:17 ; number:1 ; year:2022 ; pages:2109-2116 ; extent:8
Open medicine ; 17, Heft 1 (2022), 2109-2116 (gesamt 8)
- Creator
-
Hu, Chunhong
Zhao, Lishu
Zhou, Chengzhi
Wang, Hanping
Jiang, Shun
Li, Yizheng
Peng, Yurong
Deng, Chao
Ma, Fang
Pan, Yue
Shu, Long
Huang, Yan
Zeng, Yue
Wu, Fang
- DOI
-
10.1515/med-2022-0611
- URN
-
urn:nbn:de:101:1-2022122113054321227465
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:33 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Hu, Chunhong
- Zhao, Lishu
- Zhou, Chengzhi
- Wang, Hanping
- Jiang, Shun
- Li, Yizheng
- Peng, Yurong
- Deng, Chao
- Ma, Fang
- Pan, Yue
- Shu, Long
- Huang, Yan
- Zeng, Yue
- Wu, Fang
Other Objects (12)
Scale invariance of BMP signaling gradients in zebrafish
A tracking ADC with transient-driven self-clocking for digital DC-DC converters
Spatio-temporal evolution and distribution of cultural heritage sites along the Suzhou canal of China
Low‐Intensity Sensitive and High Stability Flexible Heart Sound Sensor Enabled by Hybrid Near‐Field/Far‐Field Electrospinning
Oxygen Reduction Reaction on PtCo Nanocatalyst: (Bi)sulfate Anion Poisoning
ARN: analysis and prediction by adipogenic professional database
Using Deep Learning and Multi-source Remote Sensing Images to Map Landlocked Lakes in Antarctica
Neuropsychiatric events in an adult patient with influenza a (H3N2) treated with oseltamivir (Tamiflu): a case report
Changes of serum CA125 and PGE2 before and after high-intensity focused ultrasound combined with GnRH-a in treatment of patients with adenomyosis
Current status and perspectives of Clonorchis sinensis and clonorchiasis: epidemiology, pathogenesis, omics, prevention and control
Identification of seven hypoxia-related genes signature and risk score models for predicting prognosis for ovarian cancer
Removal of alachlor from water by catalyzed ozonation on Cu/Al2O3honeycomb
Scale invariance of BMP signaling gradients in zebrafish
A tracking ADC with transient-driven self-clocking for digital DC-DC converters
Spatio-temporal evolution and distribution of cultural heritage sites along the Suzhou canal of China
Low‐Intensity Sensitive and High Stability Flexible Heart Sound Sensor Enabled by Hybrid Near‐Field/Far‐Field Electrospinning
Oxygen Reduction Reaction on PtCo Nanocatalyst: (Bi)sulfate Anion Poisoning
ARN: analysis and prediction by adipogenic professional database
Using Deep Learning and Multi-source Remote Sensing Images to Map Landlocked Lakes in Antarctica
Neuropsychiatric events in an adult patient with influenza a (H3N2) treated with oseltamivir (Tamiflu): a case report
Changes of serum CA125 and PGE2 before and after high-intensity focused ultrasound combined with GnRH-a in treatment of patients with adenomyosis
Current status and perspectives of Clonorchis sinensis and clonorchiasis: epidemiology, pathogenesis, omics, prevention and control
Identification of seven hypoxia-related genes signature and risk score models for predicting prognosis for ovarian cancer
Removal of alachlor from water by catalyzed ozonation on Cu/Al2O3honeycomb
Scale invariance of BMP signaling gradients in zebrafish
A tracking ADC with transient-driven self-clocking for digital DC-DC converters
Spatio-temporal evolution and distribution of cultural heritage sites along the Suzhou canal of China
Low‐Intensity Sensitive and High Stability Flexible Heart Sound Sensor Enabled by Hybrid Near‐Field/Far‐Field Electrospinning
Oxygen Reduction Reaction on PtCo Nanocatalyst: (Bi)sulfate Anion Poisoning
ARN: analysis and prediction by adipogenic professional database
Using Deep Learning and Multi-source Remote Sensing Images to Map Landlocked Lakes in Antarctica
Neuropsychiatric events in an adult patient with influenza a (H3N2) treated with oseltamivir (Tamiflu): a case report
Changes of serum CA125 and PGE2 before and after high-intensity focused ultrasound combined with GnRH-a in treatment of patients with adenomyosis
Current status and perspectives of Clonorchis sinensis and clonorchiasis: epidemiology, pathogenesis, omics, prevention and control
Identification of seven hypoxia-related genes signature and risk score models for predicting prognosis for ovarian cancer