Ni/Cu Dual‐Catalyzed Propargylation for the Stereodivergent Synthesis of Methohexital

to related objects

Abstract: The development of efficient methodologies for the controlled manufacture of specific stereoisomers bearing quaternary stereocenters has prompted advances in a variety of scientific disciplines including pharmaceutical chemistry, materials science, and chemical biology. However, complete control of the absolute and relative stereochemical configurations of alkyne derivatives remains an unmet synthetic challenge. Herein, a Ni/Cu dual‐catalyzed asymmetric propargylic substitution reaction is presented to produce propargylated products with all‐carbon quaternary stereocenters in high yields with significant diastereo‐ and enantioselectivities (up to >20:1 dr, >99% ee). The synthesis of all stereochemical variants of methohexital, a widely used sedative‐hypnotic drug, exemplifies the efficacy of dual‐catalyzed stereodivergent propargylation.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Ni/Cu Dual‐Catalyzed Propargylation for the Stereodivergent Synthesis of Methohexital ; day:25 ; month:07 ; year:2024 ; extent:12
Advanced science ; (25.07.2024) (gesamt 12)

Creator: Chang, Xihao
Zhang, Jiayin
Cheng, Xiang
Lv, Xianhai
Guo, Chang

DOI: 10.1002/advs.202406764

URN: urn:nbn:de:101:1-2407251414441.683942838152

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 14.08.2025, 10:47 AM CEST

Data provider

This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.

Show original at data provider

Associated

Chang, Xihao
Zhang, Jiayin
Cheng, Xiang
Lv, Xianhai
Guo, Chang

Other Objects (12)

Preparation of Ni/Cu composite nanowires

Electrodeposited Ni-Cu Coatings with Hierarchical Surface Morphology

Electrocatalytic properties of Ni–Cu structures fabricated by electrodeposition of Cu on Ni cones

Optical properties of Ni and Cu nanowire arrays and Ni/Cu superlattice nanowire arrays

Hydrogen evolution reaction measurements of dealloyed porous NiCu

Magnetism and magnetoresistance of single Ni–Cu alloy nanowires

Untersuchungen zur diffusionsinduzierten Korngrenzenwanderung und Rekristallisation in den Systemen Ni(Cu), Ni-Pd(Cu) und Ni3Al(Cu)

Inter‐Metal Interaction with a Threshold Effect in NiCu Dual‐Atom Catalysts for CO 2 Electroreduction

Hochschulschrift

Mechanismen beim Sintern mit verschwindender flüssiger Phase in den Systemen Ni-Cu und Fe-Ni

Decreased Metal Dusting Resistance of Ni-Cu Alloys by Fe and Mn Additions

SBA‐15 Supported Ni‐Cu Catalysts for Hydrodeoxygenation of m‐cresol to Toluene

Preparation of Ni/Cu composite nanowires

Electrodeposited Ni-Cu Coatings with Hierarchical Surface Morphology

Electrocatalytic properties of Ni–Cu structures fabricated by electrodeposition of Cu on Ni cones

Optical properties of Ni and Cu nanowire arrays and Ni/Cu superlattice nanowire arrays

Hydrogen evolution reaction measurements of dealloyed porous NiCu

Magnetism and magnetoresistance of single Ni–Cu alloy nanowires

Untersuchungen zur diffusionsinduzierten Korngrenzenwanderung und Rekristallisation in den Systemen Ni(Cu), Ni-Pd(Cu) und Ni3Al(Cu)

Inter‐Metal Interaction with a Threshold Effect in NiCu Dual‐Atom Catalysts for CO 2 Electroreduction

Hochschulschrift

Mechanismen beim Sintern mit verschwindender flüssiger Phase in den Systemen Ni-Cu und Fe-Ni

Decreased Metal Dusting Resistance of Ni-Cu Alloys by Fe and Mn Additions

SBA‐15 Supported Ni‐Cu Catalysts for Hydrodeoxygenation of m‐cresol to Toluene

Preparation of Ni/Cu composite nanowires

Electrodeposited Ni-Cu Coatings with Hierarchical Surface Morphology

Electrocatalytic properties of Ni–Cu structures fabricated by electrodeposition of Cu on Ni cones

Optical properties of Ni and Cu nanowire arrays and Ni/Cu superlattice nanowire arrays

Hydrogen evolution reaction measurements of dealloyed porous NiCu

Magnetism and magnetoresistance of single Ni–Cu alloy nanowires

Untersuchungen zur diffusionsinduzierten Korngrenzenwanderung und Rekristallisation in den Systemen Ni(Cu), Ni-Pd(Cu) und Ni3Al(Cu)

Inter‐Metal Interaction with a Threshold Effect in NiCu Dual‐Atom Catalysts for CO 2 Electroreduction

Hochschulschrift

Mechanismen beim Sintern mit verschwindender flüssiger Phase in den Systemen Ni-Cu und Fe-Ni

Decreased Metal Dusting Resistance of Ni-Cu Alloys by Fe and Mn Additions

SBA‐15 Supported Ni‐Cu Catalysts for Hydrodeoxygenation of m‐cresol to Toluene

Cultural heritage institutions wishing to register will find more information here.

Fields marked * need to be filled in.

Username*

Please enter your username

Email*

Please enter your email address

Please do not fill this field

First name

Last name

Password*

Please enter your password

Confirm password*

Please enter the same password

I have read and agree to the privacy policy for the collection of personal data.*

This field is required.

I would like to subscribe to the newsletter of the Deutsche Digitale Bibliothek. See newsletter subscription info.

Account created

Your "My DDB" account has been successfully created. Before you can log in to your account, you must click the confirmation link in the message we just sent to the email address you provided.

Ni/Cu Dual‐Catalyzed Propargylation for the Stereodivergent Synthesis of Methohexital

Show object

References and Relationships

Contributors, Places and Time

Further information

Data provider

Associated

Other Objects (12)

Preparation of Ni/Cu composite nanowires

Electrodeposited Ni-Cu Coatings with Hierarchical Surface Morphology

Electrocatalytic properties of Ni–Cu structures fabricated by electrodeposition of Cu on Ni cones

Optical properties of Ni and Cu nanowire arrays and Ni/Cu superlattice nanowire arrays

Hydrogen evolution reaction measurements of dealloyed porous NiCu

Magnetism and magnetoresistance of single Ni–Cu alloy nanowires

Untersuchungen zur diffusionsinduzierten Korngrenzenwanderung und Rekristallisation in den Systemen Ni(Cu), Ni-Pd(Cu) und Ni3Al(Cu)

Inter‐Metal Interaction with a Threshold Effect in NiCu Dual‐Atom Catalysts for CO 2 Electroreduction

Mechanismen beim Sintern mit verschwindender flüssiger Phase in den Systemen Ni-Cu und Fe-Ni

Decreased Metal Dusting Resistance of Ni-Cu Alloys by Fe and Mn Additions

Decreased Metal Dusting Resistance of Ni-Cu Alloys by Fe and Mn Additions

SBA‐15 Supported Ni‐Cu Catalysts for Hydrodeoxygenation of m‐cresol to Toluene

Preparation of Ni/Cu composite nanowires

Electrodeposited Ni-Cu Coatings with Hierarchical Surface Morphology

Electrocatalytic properties of Ni–Cu structures fabricated by electrodeposition of Cu on Ni cones

Optical properties of Ni and Cu nanowire arrays and Ni/Cu superlattice nanowire arrays

Hydrogen evolution reaction measurements of dealloyed porous NiCu

Magnetism and magnetoresistance of single Ni–Cu alloy nanowires

Untersuchungen zur diffusionsinduzierten Korngrenzenwanderung und Rekristallisation in den Systemen Ni(Cu), Ni-Pd(Cu) und Ni3Al(Cu)

Inter‐Metal Interaction with a Threshold Effect in NiCu Dual‐Atom Catalysts for CO 2 Electroreduction

Mechanismen beim Sintern mit verschwindender flüssiger Phase in den Systemen Ni-Cu und Fe-Ni

Decreased Metal Dusting Resistance of Ni-Cu Alloys by Fe and Mn Additions

Decreased Metal Dusting Resistance of Ni-Cu Alloys by Fe and Mn Additions

SBA‐15 Supported Ni‐Cu Catalysts for Hydrodeoxygenation of m‐cresol to Toluene

Preparation of Ni/Cu composite nanowires

Electrodeposited Ni-Cu Coatings with Hierarchical Surface Morphology

Electrocatalytic properties of Ni–Cu structures fabricated by electrodeposition of Cu on Ni cones

Optical properties of Ni and Cu nanowire arrays and Ni/Cu superlattice nanowire arrays

Hydrogen evolution reaction measurements of dealloyed porous NiCu

Magnetism and magnetoresistance of single Ni–Cu alloy nanowires

Untersuchungen zur diffusionsinduzierten Korngrenzenwanderung und Rekristallisation in den Systemen Ni(Cu), Ni-Pd(Cu) und Ni3Al(Cu)

Inter‐Metal Interaction with a Threshold Effect in NiCu Dual‐Atom Catalysts for CO 2 Electroreduction

Mechanismen beim Sintern mit verschwindender flüssiger Phase in den Systemen Ni-Cu und Fe-Ni

Decreased Metal Dusting Resistance of Ni-Cu Alloys by Fe and Mn Additions

Decreased Metal Dusting Resistance of Ni-Cu Alloys by Fe and Mn Additions

SBA‐15 Supported Ni‐Cu Catalysts for Hydrodeoxygenation of m‐cresol to Toluene

Related objects

Reset password