Therapeutic Remodeling of the Tumor Microenvironment Enhances Nanoparticle Delivery

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Abstract: A major challenge in the development of cancer nanomedicine is the inability for nanomaterials to efficiently penetrate and deliver therapeutic agents into solid tumors. Previous studies have shown that tumor vasculature and extracellular matrix regulate the transvascular and interstitial transport of nanoparticles, both critical for successfully delivering nanomedicine into solid tumors. Within the malignant tumor microenvironment, blood vessels are morphologically abnormal and functionally exhibit substantial permeability. Furthermore, the tumor extracellular matrix (ECM), unlike that of the normal tissue parenchyma, is densely packed with collagen. These pathophysiological properties greatly impede intratumoral delivery of nanomaterials. By using an antivascular endothelial growth factor receptor antibody, DC101, and an antitransforming growth factor β1 (TGF‐β1) antibody, normalization of the tumor vasculature and ECM is achieved, respectively, in a syngeneic murine glioma model. This normalization effect results in a more organized vascular network, improves tissue perfusion, and reduces collagen density, all of which contribute to enhanced nanoparticle delivery and distribution within tumors. These findings suggest that combined vascular and ECM normalization strategies can be used to remodel the tumor microenvironment and improve nanomedicine delivery into solid tumors, which has significant implications for developing more effective combinational therapeutic strategies using cancer nanomedicine.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Therapeutic Remodeling of the Tumor Microenvironment Enhances Nanoparticle Delivery ; volume:6 ; number:5 ; year:2019 ; extent:6
Advanced science ; 6, Heft 5 (2019) (gesamt 6)

Creator: Chen, Yuanxin
Liu, Xiujie
Yuan, Hengfeng
Yang, Zhaogang
von Roemeling, Christina A.
Qie, Yaqing
Zhao, Hai
Wang, Yifan
Jiang, Wen
Kim, Betty Y. S.

DOI: 10.1002/advs.201802070

URN: urn:nbn:de:101:1-2022072508183895708247

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:30 AM CEST

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Chen, Yuanxin
Liu, Xiujie
Yuan, Hengfeng
Yang, Zhaogang
von Roemeling, Christina A.
Qie, Yaqing
Zhao, Hai
Wang, Yifan
Jiang, Wen
Kim, Betty Y. S.

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Therapeutic Remodeling of the Tumor Microenvironment Enhances Nanoparticle Delivery

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