The potential of γδ CAR and TRuC T cells: An unearthed treasure

Abstract: Recent years have witnessed the success of αβ T cells engineered to express chimeric antigen receptors (CARs) in treating haematological cancers. CARs combine the tumour antigen binding capability of antibodies with the signalling functions of the T‐cell receptor (TCR) ζ chain and co‐stimulatory receptors. Despite the success, αβ CAR T cells face limitations. Possible solutions would be the use of γδ T cells and new chimeric receptors, such as TCR fusion constructs (TRuCs). Notably, γδ CAR T cells are gaining traction in pre‐clinical and clinical studies, demonstrating a promising safety profile in several pilot studies. This review delves into the current understanding of γδ CAR and TCR fusion construct T cells, exploring the opportunities and challenges they present for cancer treatment.

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• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: The potential of γδ CAR and TRuC T cells: An unearthed treasure ; day:27 ; month:08 ; year:2024 ; extent:10 ; European journal of immunology ; (27.08.2024) (gesamt 10)

Contributors, Places and Time

• Creator: Schamel, Wolfgang W. ; Zinchenko, Marina ; Nguyen, Trang ; Fehse, Boris ; Briquez, Priscilla S. ; Minguet, Susana

Further information

• DOI: 10.1002/eji.202451074
• URN: urn:nbn:de:101:1-2408281407507.815693078330
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.