Assessing vitamin D metabolism – four decades of experience
Abstract: One hundred years ago, the role of vitamin D for bone mineralization and the prevention of rickets was discovered. Vitamin D comprises a group of over 50 metabolites with multiple functions that go far beyond calcium homeostasis and bone mineralization. Approximately 50 years ago, first methods for the measurement of 25-hydroxyvitamin D (25 (OH) D) in human blood were developed. Over the years, different analytical principals were employed including competitive protein binding assays, high-performance liquid chromatography, various immunoassay and mass spectrometric formats. Until the recent standardization of serum 25 (OH) D measurement, agreement between methods was unsatisfactory. Since then, comparability has improved, but substantial variability between methods remains. With the advent of liquid chromatography tandem mass spectrometry (LC-MS/MS), the accurate determination of 25 (OH) D and other metabolites, such as 24,25 (OH) 2D, becomes increasingly accessible for clinical laboratories. Easy access to 25 (OH) D testing has triggered extensive clinical research showing that large parts of the population are vitamin D deficient. The variable response of vitamin D deficient individuals to supplementation indicates that assessing patients’ vitamin D stores by measuring 25 (OH) D provides limited insight into the metabolic situation. Meanwhile, first evidence has emerged suggesting that the simultaneous measurement of 25 (OH) D, 24,25 (OH) 2D and other metabolites allows a dynamic evaluation of patients’ vitamin D status on metabolic principals. This may help to identify patients with functional vitamin D deficiency from those without. It can be expected that research into the assessment vitamin D status will continue for another 50 years and that this will help rationalizing our approach in clinical practice.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Assessing vitamin D metabolism – four decades of experience ; volume:61 ; number:5 ; year:2023 ; pages:880-894 ; extent:015
Clinical chemistry and laboratory medicine ; 61, Heft 5 (2023), 880-894 (gesamt 015)
- Urheber
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Herrmann, Markus
- DOI
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10.1515/cclm-2022-1267
- URN
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urn:nbn:de:101:1-2023033114204136421580
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 10:59 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Herrmann, Markus
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