Association of Vitamin D Receptor Gene Polymorphisms with Chronic Periodontitis in a Population in Western Romania

Purpose: Recent data indicate that gene polymorphisms, e.g. those of vitamin D-receptor (VDR), are associated with an increased susceptibility to chronic periodontitis (CP). This study investigated whether VDR gene polymorphism is associated with chronic periodontitis in a population in Western Romania, by determining the prevalence of the BsmI (rs1544410), ApaI (rs7975232), TaqI (rs731236) and FokI (rs2228570) genotypes and comparing the CP group with a periodontally healthy group. Materials and Methods: This case-control study included 53 patients with CP and 47 healthy patients. VDR polymorphisms were genotyped using real-time polymerase chain reaction (PCR). The associations between VDR polymorphisms and CP were determined using logistic regression models, adjusted for patient age and serum level of Vitamin D. Results: We found a statistically significant association between the single nucleotide polymorphism (SNP) rs2228570 (FokI) and CP. Compared with subjects having the Thymine-Thymine (TT) genotype, those with the Cytosine-Cytosine (CC) variant were 19 times more likely to have the disease (adjusted odd ratio [OR]: 19.58; 95% confidence interval [CI]: 2.67 - 198.92) and with the Thymine-Cytosine (TC) variant, 8 times more likely (adjusted OR: 7.86; 95% CI: 1.29 - 61.56). Also, for the SNP rs1544410 (BsmI), compared with the Adenine-Adenine (AA) genotype, the Adenine-Guanine (AG) variant had an increased risk of periodontal disease (crude OR: 3.76; 95% CI: 1.15 - 13.80). Conclusion: This case-control study of a Western Romanian population shows an association between vitamin D receptor (VDR) polymorphisms (FokI and BsmI) and CP susceptibility.

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Association of Vitamin D Receptor Gene Polymorphisms with Chronic Periodontitis in a Population in Western Romania ; volume:17 ; number:2 ; year:2019 ; pages:157-165 ; Oral health & preventive dentistry ; 17, Heft 2 (2019), 157-165

Beteiligte, Orts- und Zeitangaben

• Urheber: Marian, Diana ; Rusu, Darian ; Stratul, Stefan-Ioan ; Calniceanu, Horia ; Sculean, Anton ; Anghel, Andrei

Weitere Informationen

• DOI: 10.3290/j.ohpd.a39738
• URN: urn:nbn:de:101:1-2023052113323595611742
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 14.08.2025, 10:57 MESZ