Proteomics, biomarkers, and HIV‐1: A current perspective

Despite more than three decades of extensive research, HIV‐1 infection although well controlled with cART, remains incurable. Multifactorial complexity of the viral life‐cycle poses great challenges in understanding molecular mechanisms underlying this infection and the development of biomarkers, which we hope will lead us to its eradication. For a more in‐depth understanding of how the virus interacts with host target cells, T cells and macrophages, proteomic profiling techniques that offer strategies to investigate the proteome in its entirety were employed. Here, we review proteomic studies related to HIV‐1 infection and discuss perspectives and limitations of proteomic and systems biology approaches in future studies.

Objekt anzeigen

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Proteomics, biomarkers, and HIV‐1: A current perspective ; volume:10 ; number:2 ; year:2016 ; pages:110-125 ; extent:16 ; Proteomics / Clinical applications. Clinical applications ; 10, Heft 2 (2016), 110-125 (gesamt 16)

Beteiligte, Orts- und Zeitangaben

• Urheber: Donnelly, Maire Rose ; Ciborowski, Pawel

Weitere Informationen

• DOI: 10.1002/prca.201500002
• URN: urn:nbn:de:101:1-2022111307093429261709
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.