Deep Learning based automated delineation of the intraprostatic gross tumour volume in PSMA-PET for patients with primary prostate cancer

Abstract: Purpose

With the increased use of focal radiation dose escalation for primary prostate cancer (PCa), accurate delineation of gross tumor volume (GTV) in prostate-specific membrane antigen PET (PSMA-PET) becomes crucial. Manual approaches are time-consuming and observer dependent. The purpose of this study was to create a deep learning model for the accurate delineation of the intraprostatic GTV in PSMA-PET.
Methods

A 3D U-Net was trained on 128 different 18F-PSMA-1007 PET images from three different institutions. Testing was done on 52 patients including one independent internal cohort (Freiburg: n = 19) and three independent external cohorts (Dresden: n = 14 18F-PSMA-1007, Boston: Massachusetts General Hospital (MGH): n = 9 18F-DCFPyL-PSMA and Dana-Farber Cancer Institute (DFCI): n = 10 68Ga-PSMA-11). Expert contours were generated in consensus using a validated technique. CNN predictions were compared to expert contours using Dice similarity coefficient (DSC). Co-registered whole-mount histology was used for the internal testing cohort to assess sensitivity/specificity.
Results

Median DSCs were Freiburg: 0.82 (IQR: 0.73–0.88), Dresden: 0.71 (IQR: 0.53–0.75), MGH: 0.80 (IQR: 0.64–0.83) and DFCI: 0.80 (IQR: 0.67–0.84), respectively. Median sensitivity for CNN and expert contours were 0.88 (IQR: 0.68–0.97) and 0.85 (IQR: 0.75–0.88) (p = 0.40), respectively. GTV volumes did not differ significantly (p > 0.1 for all comparisons). Median specificity of 0.83 (IQR: 0.57–0.97) and 0.88 (IQR: 0.69–0.98) were observed for CNN and expert contours (p = 0.014), respectively. CNN prediction took 3.81 seconds on average per patient.
Conclusion

The CNN was trained and tested on internal and external datasets as well as histopathology reference, achieving a fast GTV segmentation for three PSMA-PET tracers with high diagnostic accuracy comparable to manual experts

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• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch
• Notes: Radiotherapy and oncology. - 188 (2023) , 109774, ISSN: 1879-0887

Contributors, Places and Time

• Event: Veröffentlichung
• (where): Freiburg
• (who): Universität
• (when): 2023
• Creator: Holzschuh, Julius ; Mix, Michael ; Ruf, Juri ; Hölscher, Tobias ; Kotzerke, Jörg ; Vrachimis, Alexis ; Doolan, Paul ; Ilhan, Harun ; Marinescu, Ioana M. ; Spohn, Simon Konrad Benedict ; Fechter, Tobias ; Kuhn, Dejan ; Bronsert, Peter ; Gratzke, Christian ; Grosu, Radu ; Kamran, Sophia C. ; Heidari, Pedram ; Ng, Thomas S.C ; Könik, Arda ; Grosu, Anca-Ligia ; Zamboglou, Constantinos

Further information

• DOI: 10.1016/j.radonc.2023.109774
• URN: urn:nbn:de:bsz:25-freidok-2379000
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.