IRF4 in Skeletal Muscle Regulates Exercise Capacity via PTG/Glycogen Pathway

Abstract: Exercise‐induced fatigue and exhaustion are interesting areas for many researchers. Muscle glycogen is critical for physical performance. However, how glycogen metabolism is manipulated during exercise is not very clear. The aim here is to assess the impact of interferon regulatory factor 4 (IRF4) on skeletal muscle glycogen and subsequent regulation of exercise capacity. Skeletal muscle‐specific IRF4 knockout mice show normal body weight and insulin sensitivity, but better exercise capacity and increased glycogen content with unaltered triglyceride levels compared to control mice on chow diet. In contrast, mice overexpression of IRF4 displays decreased exercise capacity and lower glycogen content. Mechanistically, IRF4 regulates glycogen‐associated regulatory subunit protein targeting to glycogen (PTG) to manipulate glucose metabolism in skeletal muscle. Knockdown of PTG can reverse the effects imposed by the absence of IRF4 in vivo. These studies reveal a regulatory pathway including IRF4/PTG/glycogen synthesis on controlling exercise capacity.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: IRF4 in Skeletal Muscle Regulates Exercise Capacity via PTG/Glycogen Pathway ; volume:7 ; number:19 ; year:2020 ; extent:13 ; Advanced science ; 7, Heft 19 (2020) (gesamt 13)

Contributors, Places and Time

• Creator: Zhu, Xiaopeng ; Yao, Ting ; Wang, Ru ; Guo, Shanshan ; Wang, Xin ; Zhou, Zhenqi ; Zhang, Yan ; Zhuo, Xiaozhen ; Wang, Ruitao ; Li, John Zhong ; Liu, Tiemin ; Kong, Xingxing

Further information

• DOI: 10.1002/advs.202001502
• URN: urn:nbn:de:101:1-2022062309490770150228
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:36 AM CEST