Structure and function of spliceosomal DEAH-box ATPases
Abstract: Splicing of precursor mRNAs is a hallmark of eukaryotic cells, performed by a huge macromolecular machine, the spliceosome. Four DEAH-box ATPases are essential components of the spliceosome, which play an important role in the spliceosome activation, the splicing reaction, the release of the spliced mRNA and intron lariat, and the disassembly of the spliceosome. An integrative approach comprising X-ray crystallography, single particle cryo electron microscopy, single molecule FRET, and molecular dynamics simulations provided deep insights into the structure, dynamics and function of the spliceosomal DEAH-box ATPases.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Structure and function of spliceosomal DEAH-box ATPases ; volume:404 ; number:8-9 ; year:2023 ; pages:851-866 ; extent:16
Biological chemistry ; 404, Heft 8-9 (2023), 851-866 (gesamt 16)
- Creator
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Enders, Marieke
Neumann, Piotr
Dickmanns, Achim
Ficner, Ralf
- DOI
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10.1515/hsz-2023-0157
- URN
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urn:nbn:de:101:1-2023090714211482444306
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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18.08.20255, 6:50 AM CEST
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Associated
- Enders, Marieke
- Neumann, Piotr
- Dickmanns, Achim
- Ficner, Ralf
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Highlight: integrative structural biology of dynamic macromolecular assemblies
Functional and Structural Characterization of the DEAH-box Helicase Prp43
Regulation of DEAH-box RNA helicases by G-patch proteins
Structure-based Search for novel c-di-AMP Synthase Inhibiting Fragments
Structural insight into the recognition of amino-acylated initiator tRNA by eIF5B in the 80S initiation complex
Investigation of the 3D structure of the human activated spliceosome by cryo-electron microscopy
Structure and molecular function of WD-40 repeat-containing autophagy proteins Atg18, Atg21 and Hsv2
Novel Insights in Structure and Mechanism of Escherichia coli Transketolase
The function of Nup358 in nucleocytoplasmic transport
Structural and Functional Investigation of Promoter Distortion and Opening in the RNA Polymerase II Cleft
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Isolierung, Kristallisation und Röntgenstrukturanalyse von Phycoerythrin aus Cyanobacteria und Rhodophyta
Highlight: integrative structural biology of dynamic macromolecular assemblies
Functional and Structural Characterization of the DEAH-box Helicase Prp43
Regulation of DEAH-box RNA helicases by G-patch proteins
Structure-based Search for novel c-di-AMP Synthase Inhibiting Fragments
Structural insight into the recognition of amino-acylated initiator tRNA by eIF5B in the 80S initiation complex
Investigation of the 3D structure of the human activated spliceosome by cryo-electron microscopy
Structure and molecular function of WD-40 repeat-containing autophagy proteins Atg18, Atg21 and Hsv2
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