Cytokine profiling: variation in immune modulation with preterm birth vs. uncomplicated term birth identifies pivotal signals in pathogenesis of preterm birth

Objectives: To assess deviations in longitudinally measured cytokines with preterm birth (PTB). Methods: Prospective longitudinal study targeting 80 subjects. Phlebotomy specimens for broad panel of cytokine analysis were obtained at three time (T) intervals: first trimester (T1: 8–14 weeks’ gestation), second trimester (T2: 18–22 weeks’ gestation), and third trimester (T3: 28–32 weeks’ gestation). Important demographics and outcomes were tracked. Data were stratified and the target groups were analyzed as follows: “Uncomplicated” (delivered ≥37 weeks) or “Preterm Birth” (<37 weeks). Generalized Linear Modeling determined rate of change T1–T3 by outcome. Results: Complete data replete with phlebotomy at all three visits were obtained on 80 women. Birth outcomes were as follows: 11 Uncomplicated Term Birth (UTB), 28 PTB, 4 low birth weight (LBW), 16 OB complications (OBC), 11 current infections (IFN), and 10 mixed complications (MC=2 or more of the above). 28 PTB were compared to 11 uncomplicated term deliveries. In both groups, T helper type 1 (TH1) cytokine (IL-1β), pleiotrophic pro-inflammatory cytokine (IL-6), and counter-regulatory cytokine (IL-10) responses decreased over gestation, but rates of change in IL-1β, IL-6, and IL-10 were significantly different. Stratification of women by smoking status additionally demonstrated significant variance in immune status over the course of pregnancy Conclusions: Women delivering PTB demonstrated significant differences in cytokine trajectory over pregnancy; these data further validate key role played by immune regulation in directing pregnancy outcome. Likewise, smoking impacts longitudinal trajectory of cytokines over pregnancy.

Objekt anzeigen

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Cytokine profiling: variation in immune modulation with preterm birth vs. uncomplicated term birth identifies pivotal signals in pathogenesis of preterm birth ; volume:49 ; number:3 ; year:2021 ; pages:299-309 ; extent:11 ; Journal of perinatal medicine ; 49, Heft 3 (2021), 299-309 (gesamt 11)

Beteiligte, Orts- und Zeitangaben

• Urheber: Denney, Jeffrey M. ; Nelson, Edward ; Wadhwa, Pathick ; Waters, Thaddeus ; Mathew, Leny ; Goldenberg, Robert L. ; Culhane, Jennifer F.

Weitere Informationen

• DOI: 10.1515/jpm-2020-0025
• URN: urn:nbn:de:101:1-2023011913071566058249
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.