European survey showed wide variations in diagnostic procedures and management strategies for metabolic bone disease of prematurity in 22 countries

Abstract: Aim
The aim of this study was to evaluate the clinical relevance, diagnostic procedures and treatment strategies for metabolic bone disease in preterm infants across Europe.

Methods
An e-survey was distributed by email to 545 neonatal units in 38 European countries between July and October 2021. The protocol was based on the Checklist for Reporting Results of Internet E-Surveys.

Results
In total, 76 neonatal units (14%) from 22 European countries (58%) completed the e-survey. In the 12 months prior to the survey, 29% of 76 units reported at least one symptomatic case of fracture associated with metabolic bone disease of prematurity, and 18% of 76 units reported at least one case of craniofacial deformity. Most centres followed local guidelines for diagnosis (77% of 73 units) and treatment (63% of 72 units). Alkaline phosphatase was the blood marker most used for treatment indication (81% of 72 units), and phosphate supplementation was the treatment most used (82% of 71 units).

Conclusion
Metabolic bone disease of prematurity remains clinically relevant. Wide variations in diagnostic procedures and management strategies were observed in European neonatal units. Evidence-based consensus guidelines appear urgently needed to reduce the number of symptomatic cases

Objekt anzeigen

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch
• Anmerkungen: Acta paediatrica. - 113, 8 (2024) , 1908-1915, ISSN: 1651-2227

Beteiligte, Orts- und Zeitangaben

• Ereignis: Veröffentlichung
• (wo): Freiburg
• (wer): Universität
• (wann): 2024
• Urheber: Brado, Luise ; Matheisl, Daniel ; Mildenberger, Eva ; Fuchs, Hans ; Klotz, Daniel ; Kidszun, André

Weitere Informationen

• DOI: 10.1111/apa.17273
• URN: urn:nbn:de:bsz:25-freidok-2489322
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.