Benefits of pre-operative concurrent chemo-radiotherapy among elder patients with local advanced rectal cancer

Artikel

The pre-operative chemo-radiotherapy (Pre-OP CCRT) in aged patients with stage III rectal cancer may be less effective. We collected data from 3365 patients (2004-2012) from Taiwan Cancer Registry. Metachronous colorectal cancer and multiple cancer patients were excluded. The patients were separated in three groups, operation first, Pre-OP CCRT first and treatment without operation. SAS 9.2 Student-t, ANOVA and Chi-Square tests were used for analysis. It was found that Group II had good survival curve than the group I (HR =0.26, p<0.0001). The group III had the worst survival benefit (HR=3.38, p<0.0001). Patients with age <75 Y/O had the same survival curve (p=0.0099). Patients age between75-80Y/O had worse survival time (HR=2.91, p<0.0001). The mortality rate increased dramatically in patients old than 85Y/O but the Pre-OP CCRT still provided survival benefit (HR=6.55, p<0.0001). Pre-operative CCRT improved survival in stage III rectal cancer. Even patients with 80~85 years old still had the benefit. In old patients without major comobility and good physical status, Pre-OP CCRT was still the best choice.

Object Details

• Language: Englisch

References and Relationships

• Bibliographic citation: Journal: International Journal of Management, Economics and Social Sciences (IJMESS) ; ISSN: 2304-1366 ; Volume: 7 ; Year: 2018 ; Issue: Special Issue ; Pages: 142-154 ; Jersey City, NJ: IJMESS International Publishers

Classification and Topics

• Classification: Wirtschaft
• Subject: Pre-operative concurrent chemo-radiotherapy (Pre-op CCRT) ; rectal cancer ; local recurrence ; survival time

Contributors, Places and Time

• Event: Geistige Schöpfung
• (who): Ting, Wen-Chien ; Yeh, Chih-Jung
• Event: Veröffentlichung
• (who): IJMESS International Publishers
• (where): Jersey City, NJ
• (when): 2018

Further information

• Handle: http://hdl.handle.net/10419/176840
• Last update: 10.03.2025, 11:44 AM CET