Macrophages - HIV-induced Syncytia Formation in Human Monocytes/Macrophages

zweidimensionales bewegtes Bild

With the help of time-lapse phase contrast photography (1:200 to 1:6000) it is possible to follow HIV-induced cell fusion and the formation of syncytia in monocyte/macrophages isolated from human blood. Syncytia are rarely seen in normal cell culture. The infection of monocyte/macrophages by viruses, for example human immunodeficiency virus (HIV), induces fusion between these cells which results in large multi-nucleated syncytia. In HIV-infected macrophages that have been in culture for a number of weeks these syncytia can reach a significant size and contain dozens of nuclei. The film further demonstrates not only the formation of syncytia through HIV-induced cell fusion, but also specifically the dynamics of this process, the kinetics of cell fusion and syncytia formation as well as the nature of the involvement of macrophage subtypes.

Object Details

• Alternative title: Makrophagen - HIV-induzierte Synzytienbildung bei humanen Monozyten/Makrophagen
• Location: Hannover TIB
• Extent: 126MB, 00:10:16:06 (unknown)
• Language: Englisch
• Notes: Audiovisuelles Material

References and Relationships

• Bibliographic citation: Macrophages - HIV-induced Syncytia Formation in Human Monocytes/Macrophages ; (Jan. 1993)

Classification and Topics

• Keyword: macrophages ; Medizin ; medical microbiology ; monocytes ; cytopathic effect (CPE) ; mononuclear phagocyte system (MPS) ; cytopathological effect ; syncytia ; HIV ; Medizinische Mikrobiologie ; giant cells ; medicine

Contributors, Places and Time

• Event: Veröffentlichung
• (who): IWF (Göttingen)
• (when): 1993-01-01
• Contributor: Briesen, Hagen von ; Rübsamen-Waigmann, Helga ; Kreutz, Marina ; Andreesen, Reinhard

Further information

• DOI: 10.3203/IWF/C-1815eng
• Last update: 01.04.0020, 8:09 AM CET