A set point in the selection of the αβTCR T cell repertoire imposed by pre-TCR signaling strength : = A set point in the selection of the [alpha][beta]TCR T cell repertoire imposed by pre-TCR signaling strength
Abstract: Signaling via the T cell receptor (TCR) is critical during the development, maintenance, and activation of T cells. Quantitative aspects of TCR signaling have an important role during positive and negative selection, lineage choice, and ability to respond to small amounts of antigen. By using a mutant mouse line expressing a hypomorphic allele of the CD3ζ chain, we show here that the strength of pre-TCR–mediated signaling during T cell development determines the diversity of the TCRβ repertoire available for positive and negative selection, and hence of the final αβTCR repertoire. This finding uncovers an unexpected, pre-TCR signaling–dependent and repertoire–shaping role for β-selection beyond selection of in-frame rearranged TCRβ chains. Our data furthermore support a model of pre-TCR signaling in which the arrangement of this receptor in stable nanoclusters determines its quantitative signaling capacity
- Weitere Titel
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A set point in the selection of the [alpha][beta]TCR T cell repertoire imposed by pre-TCR signaling strength
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Anmerkungen
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Proceedings of the National Academy of Sciences of the United States of America. - 119, 22 (2022) , e2201907119, ISSN: 1091-6490
- Ereignis
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Veröffentlichung
- (wo)
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Freiburg
- (wer)
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Universität
- (wann)
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2024
- Urheber
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Rodríguez‐Bovolenta, Elena
García-Cuesta, Eva M.
Horndler, Lydia
Ponomarenko, Julia
Schamel, Wolfgang
Mellado, Mario
Castro, Mario
Abia, David
Santen, Hisse M. van
- DOI
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10.1073/pnas.2201907119
- URN
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urn:nbn:de:bsz:25-freidok-2447574
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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25.03.2025, 13:56 MEZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Rodríguez‐Bovolenta, Elena
- García-Cuesta, Eva M.
- Horndler, Lydia
- Ponomarenko, Julia
- Schamel, Wolfgang
- Mellado, Mario
- Castro, Mario
- Abia, David
- Santen, Hisse M. van
- Universität
Entstanden
- 2024
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