A set point in the selection of the αβTCR T cell repertoire imposed by pre-TCR signaling strength : = A set point in the selection of the [alpha][beta]TCR T cell repertoire imposed by pre-TCR signaling strength

Abstract: Signaling via the T cell receptor (TCR) is critical during the development, maintenance, and activation of T cells. Quantitative aspects of TCR signaling have an important role during positive and negative selection, lineage choice, and ability to respond to small amounts of antigen. By using a mutant mouse line expressing a hypomorphic allele of the CD3ζ chain, we show here that the strength of pre-TCR–mediated signaling during T cell development determines the diversity of the TCRβ repertoire available for positive and negative selection, and hence of the final αβTCR repertoire. This finding uncovers an unexpected, pre-TCR signaling–dependent and repertoire–shaping role for β-selection beyond selection of in-frame rearranged TCRβ chains. Our data furthermore support a model of pre-TCR signaling in which the arrangement of this receptor in stable nanoclusters determines its quantitative signaling capacity

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• Alternative title: A set point in the selection of the [alpha][beta]TCR T cell repertoire imposed by pre-TCR signaling strength
• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch
• Notes: Proceedings of the National Academy of Sciences of the United States of America. - 119, 22 (2022) , e2201907119, ISSN: 1091-6490

Contributors, Places and Time

• Event: Veröffentlichung
• (where): Freiburg
• (who): Universität
• (when): 2024
• Creator: Rodríguez‐Bovolenta, Elena ; García-Cuesta, Eva M. ; Horndler, Lydia ; Ponomarenko, Julia ; Schamel, Wolfgang ; Mellado, Mario ; Castro, Mario ; Abia, David ; Santen, Hisse M. van

Further information

• DOI: 10.1073/pnas.2201907119
• URN: urn:nbn:de:bsz:25-freidok-2447574
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.