BH3 mimetics for the treatment of prostate cancer
Abstract: Despite improved diagnostic and therapeutic intervention, advanced prostate cancer (PC) remains incurable. The acquired resistance of PC cells to current treatment protocols has been traced to apoptosis resistance based on the upregulation of anti-apoptotic proteins of the Bcl-2 family. The use of BH3 mimetics, mimicking pro-apoptotic activator or sensitizer proteins of the intrinsic apoptotic pathway, is therefore a promising treatment strategy. The present review gives an overview of preclinical and clinical studies with pan- and specific BH3 mimetics as sensitizers for cell death and gives an outlook how they could be effectively used for the therapy of advanced PC in future
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Anmerkungen
-
Frontiers in pharmacology. - 8 (2017) , 00557, ISSN: 1663-9812
- DOI
-
10.3389/fphar.2017.00557
- URN
-
urn:nbn:de:bsz:25-freidok-2208129
- Rechteinformation
-
Kein Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
25.03.2025, 13:50 MEZ
Datenpartner
Dieses Objekt wird bereitgestellt von:
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Wolf, Philipp
- Universität
Entstanden
- 2021
Ähnliche Objekte (12)
Targeted toxins for the treatment of prostate cancer
[177Lu]Lu-PSMA-617 (PluvictoTM): the first FDA-approved radiotherapeutical for treatment of prostate cancer
Editorial: Advances in radiotherapy for prostate cancer
Fortifying the treatment of prostate cancer with physical activity
Adjuvant Hormonal Treatment for Prostate Cancer: The Bicalutamide Early Prostate Cancer Program
Curative Treatment of Prostate Cancer
Editorial: Exploring the potential of PSMA-PET imaging on personalized prostate cancer treatment
Dosimetric benefits of daily treatment plan adaptation for prostate cancer stereotactic body radiotherapy
Hormonal treatment of advanced prostate cancer
Treatment of prostate cancer : beyond prostatectomy
Pseudomonas exotoxin a based toxins targeting epidermal growth factor receptor for the treatment of prostate cancer
Tumor-specific induction of the iIntrinsic apoptotic pathway - a new therapeutic option for advanced prostate cancer?
Targeted toxins for the treatment of prostate cancer
[177Lu]Lu-PSMA-617 (PluvictoTM): the first FDA-approved radiotherapeutical for treatment of prostate cancer
Editorial: Advances in radiotherapy for prostate cancer
Fortifying the treatment of prostate cancer with physical activity
Adjuvant Hormonal Treatment for Prostate Cancer: The Bicalutamide Early Prostate Cancer Program
Curative Treatment of Prostate Cancer
Editorial: Exploring the potential of PSMA-PET imaging on personalized prostate cancer treatment
Dosimetric benefits of daily treatment plan adaptation for prostate cancer stereotactic body radiotherapy
Hormonal treatment of advanced prostate cancer
Treatment of prostate cancer : beyond prostatectomy
Pseudomonas exotoxin a based toxins targeting epidermal growth factor receptor for the treatment of prostate cancer
Tumor-specific induction of the iIntrinsic apoptotic pathway - a new therapeutic option for advanced prostate cancer?
Targeted toxins for the treatment of prostate cancer
[177Lu]Lu-PSMA-617 (PluvictoTM): the first FDA-approved radiotherapeutical for treatment of prostate cancer
Editorial: Advances in radiotherapy for prostate cancer
Fortifying the treatment of prostate cancer with physical activity
Adjuvant Hormonal Treatment for Prostate Cancer: The Bicalutamide Early Prostate Cancer Program
Curative Treatment of Prostate Cancer
Editorial: Exploring the potential of PSMA-PET imaging on personalized prostate cancer treatment
Dosimetric benefits of daily treatment plan adaptation for prostate cancer stereotactic body radiotherapy
Hormonal treatment of advanced prostate cancer
Treatment of prostate cancer : beyond prostatectomy
Pseudomonas exotoxin a based toxins targeting epidermal growth factor receptor for the treatment of prostate cancer