The role of E-cadherin - 160C/A polymorphism in breast cancer
Abstract: Breast cancer is the most prevalent cancer in women worldwide. Numerous studies have suggested that the E-cadherin adhesion system is dysregulated in cancer cells. These impaired functions of E-cadherin contribute to releasing cancer cells from the primary lesion to cell dedifferentiation. Some studies have shown that polymorphism may affect E-cadherin expression, and then play a role in susceptibility to breast cancer. However, the results remained controversial. In this short review, we summarize the functions of E-cadherin and the signaling pathways it regulates, and assess the association between CDH1 polymorphisms and breast cancer susceptibility. This study suggests that genetic variation in CDH1 and -160C/A polymorphism may have an association with breast cancer risk. The assessment of CDH1 polymorphisms may be used for the identification of patients suitable for anti- CDH1 therapy.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
The role of E-cadherin - 160C/A polymorphism in breast cancer ; volume:11 ; number:1 ; year:2016 ; pages:110-115 ; extent:6
Open life sciences ; 11, Heft 1 (2016), 110-115 (gesamt 6)
- Creator
-
Luo, Gaojian
Huang, Diyu
Tao, Ran
Chen, Jianfeng
- DOI
-
10.1515/biol-2016-0015
- URN
-
urn:nbn:de:101:1-2409201629590.847409978570
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
- 15.08.20252025, 5:12 AM CEST
Data provider
This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Luo, Gaojian
- Huang, Diyu
- Tao, Ran
- Chen, Jianfeng
Other Objects (12)
China's state-owned banks' lending practices, 1994-2005: Empirical tests and policy implications
Polyarylene‐Based Anion Exchange Membranes for Fuel Cells
The Size of Individual Social Networks and Rural-Urban Migrants’ Wages—Findings from a Survey of Migrants in China’s 6 Provinces and 12 Cities
A Robust Effect Size Index
A synergetic layered inorganic–organic hybrid film for conductive, flexible, and transparent electrodes
Relationship between sampling and multirate filterbanks in the linear canonical transform domain
E-cadherin to P-cadherin switching in lobular breast cancer with tubular elements
Surface and bulk acoustic wave resonators based on aluminum nitride for bandpass filters
Correction to: Effect of forceful suction and air disinfection machines on aerosol removal
Modeling and Emulating a Physiotherapist's Role in Robot‐Assisted Rehabilitation
Effect of forceful suction and air disinfection machines on aerosol removal
E-cadherin genetic variants predict survival outcome in breast cancer patients
China's state-owned banks' lending practices, 1994-2005: Empirical tests and policy implications
Polyarylene‐Based Anion Exchange Membranes for Fuel Cells
The Size of Individual Social Networks and Rural-Urban Migrants’ Wages—Findings from a Survey of Migrants in China’s 6 Provinces and 12 Cities
A Robust Effect Size Index
A synergetic layered inorganic–organic hybrid film for conductive, flexible, and transparent electrodes
Relationship between sampling and multirate filterbanks in the linear canonical transform domain
E-cadherin to P-cadherin switching in lobular breast cancer with tubular elements
Surface and bulk acoustic wave resonators based on aluminum nitride for bandpass filters
Correction to: Effect of forceful suction and air disinfection machines on aerosol removal
Modeling and Emulating a Physiotherapist's Role in Robot‐Assisted Rehabilitation
Effect of forceful suction and air disinfection machines on aerosol removal
E-cadherin genetic variants predict survival outcome in breast cancer patients
China's state-owned banks' lending practices, 1994-2005: Empirical tests and policy implications
Polyarylene‐Based Anion Exchange Membranes for Fuel Cells
The Size of Individual Social Networks and Rural-Urban Migrants’ Wages—Findings from a Survey of Migrants in China’s 6 Provinces and 12 Cities
A Robust Effect Size Index
A synergetic layered inorganic–organic hybrid film for conductive, flexible, and transparent electrodes
Relationship between sampling and multirate filterbanks in the linear canonical transform domain
E-cadherin to P-cadherin switching in lobular breast cancer with tubular elements
Surface and bulk acoustic wave resonators based on aluminum nitride for bandpass filters
Correction to: Effect of forceful suction and air disinfection machines on aerosol removal
Modeling and Emulating a Physiotherapist's Role in Robot‐Assisted Rehabilitation
Effect of forceful suction and air disinfection machines on aerosol removal