Modeling the Progression of Placental Transport from Early‐ to Late‐Stage Pregnancy by Tuning Trophoblast Differentiation and Vascularization
Abstract: The early‐stage placental barrier is characterized by a lack of fetal circulation and by a thick trophoblastic barrier, whereas the later‐stage placenta consists of vascularized chorionic villi encased in a thin, differentiated trophoblast layer, ideal for nutrient transport. In this work, predictive models of early‐ and late‐stage placental transport are created using blastocyst‐derived placental stem cells (PSCs) by modulating PSC differentiation and model vascularization. PSC differentiation results in a thinner, fused trophoblast layer, as well as an increase in human chorionic gonadotropin secretion, barrier permeability, and secretion of certain inflammatory cytokines, which are consistent with in vivo findings. Further, gene expression confirms this shift toward a differentiated trophoblast subtype. Vascularization results in a molecule type‐ and size‐dependent change in dextran and insulin permeability. These results demonstrate that trophoblast differentiation and vascularization have critical effects on placental barrier permeability and that this model can be used as a predictive measure to assess fetal toxicity of xenobiotic substances at different stages of pregnancy.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Modeling the Progression of Placental Transport from Early‐ to Late‐Stage Pregnancy by Tuning Trophoblast Differentiation and Vascularization ; day:07 ; month:11 ; year:2023 ; extent:18
Advanced healthcare materials ; (07.11.2023) (gesamt 18)
- Creator
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Kouthouridis, Sonya
Sotra, Alexander
Khan, Zaim
Alvarado, Justin
Raha, Sandeep
Zhang, Boyang
- DOI
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10.1002/adhm.202301428
- URN
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urn:nbn:de:101:1-2023110814044330686236
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
- 14.08.2025, 11:00 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Kouthouridis, Sonya
- Sotra, Alexander
- Khan, Zaim
- Alvarado, Justin
- Raha, Sandeep
- Zhang, Boyang
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Trophoblast stem cell-based organoid models of the human placental barrier
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Trophoblast stem cell-based organoid models of the human placental barrier
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