Ultrasound‐Mediated Antibiotic Delivery to In Vivo Biofilm Infections: A Review
Abstract: Bacterial biofilms are a significant concern in various medical contexts due to their resilience to our immune system as well as antibiotic therapy. Biofilms often require surgical removal and frequently lead to recurrent or chronic infections. Therefore, there is an urgent need for improved strategies to treat biofilm infections. Ultrasound‐mediated drug delivery is a technique that combines ultrasound application, often with the administration of acoustically‐active agents, to enhance drug delivery to specific target tissues or cells within the body. This method involves using ultrasound waves to assist in the transportation or activation of medications, improving their penetration, distribution, and efficacy at the desired site. The advantages of ultrasound‐mediated drug delivery include targeted and localized delivery, reduced systemic side effects, and improved efficacy of the drug at lower doses. This review scrutinizes recent advances in the application of ultrasound‐mediated drug delivery for treating biofilm infections, focusing on in vivo studies. We examine the strengths and limitations of this technology in the context of wound infections, device‐associated infections, lung infections and abscesses, and discuss current gaps in knowledge and clinical translation considerations.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Ultrasound‐Mediated Antibiotic Delivery to In Vivo Biofilm Infections: A Review ; day:14 ; month:08 ; year:2024 ; extent:22
ChemBioChem ; (14.08.2024) (gesamt 22)
- Urheber
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Liu, Jamie D.
Van Treeck, Kelly E.
Marston, William A.
Papadopoulou, Virginie
Rowe, Sarah E.
- DOI
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10.1002/cbic.202400181
- URN
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urn:nbn:de:101:1-2408151417523.995686037878
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
- 14.08.2025, 10:51 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Liu, Jamie D.
- Van Treeck, Kelly E.
- Marston, William A.
- Papadopoulou, Virginie
- Rowe, Sarah E.
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