Tailored Fluorosurfactants through Controlled/Living Radical Polymerization for Highly Stable Microfluidic Droplet Generation
Abstract: Droplet‐based microfluidics represents a disruptive technology in the field of chemistry and biology through the generation and manipulation of sub‐microlitre droplets. To avoid droplet coalescence, fluoropolymer‐based surfactants are commonly used to reduce the interfacial tension between two immiscible phases to stabilize droplet interfaces. However, the conventional preparation of fluorosurfactants involves multiple steps of conjugation reactions between fluorinated and hydrophilic segments to form multiple‐block copolymers. In addition, synthesis of customized surfactants with tailored properties is challenging due to the complex synthesis process. Here, we report a highly efficient synthetic method that utilizes living radical polymerization (LRP) to produce fluorosurfactants with tailored functionalities. Compared to the commercialized surfactant, our surfactants outperform in thermal cycling for polymerase chain reaction (PCR) testing, and exhibit exceptional biocompatibility for cell and yeast culturing in a double‐emulsion system. This breakthrough synthetic approach has the potential to revolutionize the field of droplet‐based microfluidics by enabling the development of novel designs that generate droplets with superior stability and functionality for a wide range of applications.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Tailored Fluorosurfactants through Controlled/Living Radical Polymerization for Highly Stable Microfluidic Droplet Generation ; day:12 ; month:12 ; year:2023 ; extent:10
Angewandte Chemie ; (12.12.2023) (gesamt 10)
- Creator
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Li, Xiangke
Tang, Shi‐Yang
Zhang, Yang
Zhu, Jiayuan
Forgham, Helen
Zhao, Chun‐Xia
Zhang, Cheng
Davis, Thomas P.
Qiao, Ruirui
- DOI
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10.1002/ange.202315552
- URN
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urn:nbn:de:101:1-2023121314124436616822
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:26 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Li, Xiangke
- Tang, Shi‐Yang
- Zhang, Yang
- Zhu, Jiayuan
- Forgham, Helen
- Zhao, Chun‐Xia
- Zhang, Cheng
- Davis, Thomas P.
- Qiao, Ruirui
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Global experiences in flood management – perspectives through ICFM Webinar Series
Preparation of alginate hydrogel microparticles by gelation introducing cross-linkers using droplet-based microfluidics: a review of methods
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Activating α7nAChR suppresses systemic inflammation by mitigating neuroinflammation of the medullary visceral zone in sepsis in a rat model
Tailored Fluorosurfactants through Controlled/Living Radical Polymerization for Highly Stable Microfluidic Droplet Generation
Global experiences in flood management – perspectives through ICFM Webinar Series
Preparation of alginate hydrogel microparticles by gelation introducing cross-linkers using droplet-based microfluidics: a review of methods
Poorer prognosis of ovarian squamous cell carcinoma than serous carcinoma: a propensity score matching analysis based on the SEER database
Automated vision system for fabric defect inspection using Gabor filters and PCNN
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Obesity and 1-year all-cause survival of adult intensive care patients with heart failure: data from the MIMIC-IV
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