Epigenetic Regulation during Primordial Germ Cell Development and Differentiation

Germline development varies significantly across metazoans. However, mammalian primordial germ cell (PGC) development has key conserved landmarks, including a critical period of epigenetic reprogramming that precedes sex-specific differentiation and gametogenesis. Epigenetic alterations in the germline are of unique importance due to their potential to impact the next generation. Therefore, regulation of, and by, the non-coding genome is of utmost importance during these epigenomic events. Here, we detail the key chromatin changes that occur during mammalian PGC development and how these interact with the expression of non-coding RNAs alongside broader epitranscriptomic changes. We identify gaps in our current knowledge, in particular regarding epigenetic regulation in the human germline, and we highlight important areas of future research.

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch

Erschienen in
Epigenetic Regulation during Primordial Germ Cell Development and Differentiation ; volume:15 ; number:5-6 ; year:2021 ; pages:411-431 ; extent:21
Sexual development ; 15, Heft 5-6 (2021), 411-431 (gesamt 21)

Urheber
Ramakrishna, Navin B.
Murison, Keir
Miska, Eric
Leitch, Harry G.

DOI
10.1159/000520412
URN
urn:nbn:de:101:1-2021122223143264854344
Rechteinformation
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
15.08.2025, 07:26 MESZ

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Beteiligte

  • Ramakrishna, Navin B.
  • Murison, Keir
  • Miska, Eric
  • Leitch, Harry G.

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