Rhodium‐Catalyzed C−H Methylation and Alkylation Reactions by Carbene‐Transfer Reactions
Abstract: In this combined computational and experimental study, the C−H functionalization of 2‐phenyl pyridine with diazoalkanes was investigated. Initial evaluation by computational methods allowed the evaluation of different metal catalysts and diazoalkanes and their compatibility in this C−H functionalization reaction. With these findings, suitable reaction conditions for the C−H methylation reactions were quickly identified by using highly reactive TMS diazomethane and C−H alkylation reactions with donor/acceptor diazoalkanes, which is applied to a broad scope on alkylation reactions of 2‐aryl pyridines with TMS diazomethane and donor/acceptor diazoalkane (51 examples, up to 98 % yield).
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
Rhodium‐Catalyzed C−H Methylation and Alkylation Reactions by Carbene‐Transfer Reactions ; day:02 ; month:02 ; year:2022 ; extent:1
Chemistry - a European journal ; (02.02.2022) (gesamt 1)
- Urheber
- DOI
-
10.1002/chem.202104321
- URN
-
urn:nbn:de:101:1-2022020314042143568783
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
- 15.08.2025, 07:30 MESZ
Datenpartner
Dieses Objekt wird bereitgestellt von:
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Empel, Claire
- Jana, Sripati
- Langletz, Tim
- Koenigs, Rene M.
Ähnliche Objekte (12)
Rhodium‐Catalyzed C−H Methylation and Alkylation Reactions by Carbene‐Transfer Reactions
Development of copper-, silver-, and rhodium-catalyzed coupling reactions
Rhodium-catalyzed direct alkylation of benzylic amines using alkyl bromides
Rhodium-Catalyzed Enantioselective Desymmetrization
1,3‐Difunctionalization of Imino‐Carbenes via Rhodium‐Catalyzed Reactions of Triazoles with Acyl Selenides
Rhodium-catalyzed cascade reactions of triazoles with organoselenium compounds – a combined experimental and mechanistic study
Enantioselective Rhodium‐Catalyzed Pauson–Khand Reactions of 1,6‐Chloroenynes with 1,1‐Disubstituted Olefins
Enantioselective Rhodium‐Catalyzed Pauson–Khand Reactions of 1,6‐Chloroenynes with 1,1‐Disubstituted Olefins
1,3-Difunctionalization of Imino-Carbenes via Rhodium-Catalyzed Reactions of Triazoles with Acyl Selenides
Development of carbene transfer reactions and nitrene transfer reactions
Modern rhodium catalyzed organic reactions
Rhodium-Catalyzed Asymmetric Transfer Hydrogenation
Rhodium‐Catalyzed C−H Methylation and Alkylation Reactions by Carbene‐Transfer Reactions
Development of copper-, silver-, and rhodium-catalyzed coupling reactions
Rhodium-catalyzed direct alkylation of benzylic amines using alkyl bromides
Rhodium-Catalyzed Enantioselective Desymmetrization
1,3‐Difunctionalization of Imino‐Carbenes via Rhodium‐Catalyzed Reactions of Triazoles with Acyl Selenides
Rhodium-catalyzed cascade reactions of triazoles with organoselenium compounds – a combined experimental and mechanistic study
Enantioselective Rhodium‐Catalyzed Pauson–Khand Reactions of 1,6‐Chloroenynes with 1,1‐Disubstituted Olefins
Enantioselective Rhodium‐Catalyzed Pauson–Khand Reactions of 1,6‐Chloroenynes with 1,1‐Disubstituted Olefins
1,3-Difunctionalization of Imino-Carbenes via Rhodium-Catalyzed Reactions of Triazoles with Acyl Selenides
Development of carbene transfer reactions and nitrene transfer reactions
Modern rhodium catalyzed organic reactions
Rhodium-Catalyzed Asymmetric Transfer Hydrogenation
Rhodium‐Catalyzed C−H Methylation and Alkylation Reactions by Carbene‐Transfer Reactions
Development of copper-, silver-, and rhodium-catalyzed coupling reactions
Rhodium-catalyzed direct alkylation of benzylic amines using alkyl bromides
Rhodium-Catalyzed Enantioselective Desymmetrization
1,3‐Difunctionalization of Imino‐Carbenes via Rhodium‐Catalyzed Reactions of Triazoles with Acyl Selenides
Rhodium-catalyzed cascade reactions of triazoles with organoselenium compounds – a combined experimental and mechanistic study
Enantioselective Rhodium‐Catalyzed Pauson–Khand Reactions of 1,6‐Chloroenynes with 1,1‐Disubstituted Olefins
Enantioselective Rhodium‐Catalyzed Pauson–Khand Reactions of 1,6‐Chloroenynes with 1,1‐Disubstituted Olefins
1,3-Difunctionalization of Imino-Carbenes via Rhodium-Catalyzed Reactions of Triazoles with Acyl Selenides
Development of carbene transfer reactions and nitrene transfer reactions
Modern rhodium catalyzed organic reactions