Strategies to gain novel Alzheimer’s disease diagnostics and therapeutics using modulators of ABCA transporters

Abstract: Adenosine-triphosphate-(ATP)-binding cassette (ABC) transport proteins are ubiquitously present membrane-bound efflux pumps that distribute endo- and xenobiotics across intra- and intercellular barriers. Discovered over 40 years ago, ABC transporters have been identified as key players in various human diseases, such as multidrug-resistant cancer and atherosclerosis, but also neurodegenerative diseases, such as Alzheimer’s disease (AD). Most prominent and well-studied are ABCB1, ABCC1, and ABCG2, not only due to their contribution to the multidrug resistance (MDR) phenotype in cancer, but also due to their contribution to AD. However, our understanding of other ABC transporters is limited, and most of the 49 human ABC transporters have been largely neglected as potential targets for novel small-molecule drugs. This is especially true for the ABCA subfamily, which contains several members known to play a role in AD initiation and progression. This review provides up-to-date informat.... https://www.uni-muenster.de/Ejournals/index.php/fnp/article/view/3528

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Strategies to gain novel Alzheimer’s disease diagnostics and therapeutics using modulators of ABCA transporters ; volume:2 ; day:13 ; month:12 ; year:2021 ; Free Neuropathology ; 2 (13.12.2021)

Contributors, Places and Time

• Creator: Pahnke, Jens ; Bascuñana, Pablo ; Brackhan, Mirjam ; Stefan, Katja ; Namasivayam, Vigneshwaran ; Koldamova, Radosveta ; Wu, Jingyun ; Möhle, Luisa ; Schmitt, Sven Marcel

Further information

• DOI: 10.17879/freeneuropathology-2021-3528
• URN: urn:nbn:de:hbz:6:3-freeneuropathology-2021-37192
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:23 AM CEST