Cognitive Behavioral Therapy for Late-Life Depression (CBTlate): Results of a Multicenter, Randomized, Observer-Blinded, Controlled Trial

Introduction: Different psychotherapeutic interventions for late-life depression (LLD) have been proposed, but their evaluation in large, multicenter trials is rare. Objective: The present study evaluated the efficacy of a specific cognitive behavioral therapy (CBT) for LLD (LLD-CBT) in comparison with a supportive unspecific intervention (SUI), both administered in a specialist psychiatric outpatient setting. Methods: In this randomized, controlled, parallel group trial, we recruited participants (≥60 years) with moderate to severe depression at 7 trial sites in Germany. Participants were randomly assigned to the LLD-CBT or SUI group. The primary outcome was depression severity at the end of treatment measured by change on the Geriatric Depression Scale (GDS). Secondary outcomes included change in observer-rated depression, anxiety, sleep ratings, and quality of life throughout the treatment phase and at 6-month follow-up. Results: Between October 1, 2018, and November 11, 2020, we randomly assigned 251 patients to either LLD-CBT (n = 126) or SUI (n = 125), of whom 229 provided primary-outcome data. There was no significant between-group difference in the change in GDS scores at the end of treatment (estimated marginal mean difference: −1.01 [95% CI: −2.88 to 0.86]; p = 0.287). Secondary analyses showed significant improvements in several outcomes after 8 weeks and at follow-up in both treatment arms. Conclusions: Our data suggest that LLD-specific CBT and a supportive unspecific treatment both provide clinical benefit in patients with moderate to severe LLD without evidence for superiority of LLD-CBT.

Objekt anzeigen

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Cognitive Behavioral Therapy for Late-Life Depression (CBTlate): Results of a Multicenter, Randomized, Observer-Blinded, Controlled Trial ; volume:92 ; number:3 ; year:2023 ; pages:180-192 ; extent:13 ; Psychotherapy and psychosomatics ; 92, Heft 3 (2023), 180-192 (gesamt 13)

Beteiligte, Orts- und Zeitangaben

• Urheber: Dafsari, Forugh Salimi ; Bewernick, Bettina ; Böhringer, Sabine ; Domschke, Katharina ; Elsaeßer, Moritz ; Löbner, Margrit ; Luppa, Melanie ; Preis, Lukas ; Püsken, Julia ; Schmitt, Sandra ; Szekely, Andreea-Johanna ; Hellmich, Martin ; Müller, Wiebke ; Wagner, Michael ; Peters, Oliver ; Frölich, Lutz ; Riedel-Heller, Steffi Gerlinde ; Schramm, Elisabeth ; Hautzinger, Martin ; Jessen, Frank

Weitere Informationen

• DOI: 10.1159/000529445
• URN: urn:nbn:de:101:1-2023062900151643700036
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.