Asymptomatic and pre-symptomatic infection in Coronavirus Disease 2019 pandemic

Abstract: With the presence of Coronavirus Disease 2019 (COVID-19) asymptomatic infections detected, their proportion, transmission potential, and other aspects such as immunity and related emerging challenges have attracted people’s attention. We have found that based on high-quality research, asymptomatic infections account for at least one-third of the total cases, whereas based on systematic review and meta-analysis, the proportion is about one-fifth. Evaluating the true transmission potential of asymptomatic cases is difficult but critical, since it may affect national policies in response to COVID-19. We have summarized the current evidence and found, compared with symptomatic cases, the transmission capacity of asymptomatic individuals is weaker, even though they have similar viral load and relatively short virus shedding duration. As the outbreak progresses, asymptomatic infections have also been found to develop long COVID-19. In addition, the role of asymptomatic infection in COVID-19 remains to be further revealed as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants continue to emerge. Nevertheless, as asymptomatic infections transmit the SARS-CoV-2 virus silently, they still pose a substantial threat to public health. Therefore, it is essential to conduct screening to obtain more knowledge about the asymptomatic infections and to detect them as soon as possible; meanwhile, management of them is also a key point in the fight against COVID-19 community transmission. The different management of asymptomatic infections in various countries are compared and the experience in China is displayed in detail.

Location
Deutsche Nationalbibliothek Frankfurt am Main
Extent
Online-Ressource
Language
Englisch

Bibliographic citation
Asymptomatic and pre-symptomatic infection in Coronavirus Disease 2019 pandemic ; volume:2 ; number:1 ; year:2022 ; pages:66-88 ; extent:023
Medical Review ; 2, Heft 1 (2022), 66-88 (gesamt 023)

Creator
Wang, Yutong
Zheng, Ke
Gao, Wenjing
Lv, Jun
Yu, Canqing
Wang, Lan
Wang, Zijun
Wang, Bo
Liao, Chunxiao
Li, Liming

DOI
10.1515/mr-2021-0034
URN
urn:nbn:de:101:1-2022101314283269747719
Rights
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Last update
15.08.2025, 7:25 AM CEST

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Associated

  • Wang, Yutong
  • Zheng, Ke
  • Gao, Wenjing
  • Lv, Jun
  • Yu, Canqing
  • Wang, Lan
  • Wang, Zijun
  • Wang, Bo
  • Liao, Chunxiao
  • Li, Liming

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