InterCellDB: A User‐Defined Database for Inferring Intercellular Networks
Abstract: Recent advances in single cell RNA sequencing (scRNA‐seq) empower insights into cell–cell crosstalk within specific tissues. However, customizable data analysis tools that decipher intercellular communication from gene expression in association with biological functions are lacking. The authors have developed InterCellDB, a platform that allows a user‐defined analysis of intercellular communication using scRNA‐seq datasets in combination with protein annotation information, including cellular localization and functional classification, and protein interaction properties. The application of InterCellDB in tumor microenvironment research is exemplified using two independent scRNA‐seq datasets from human and mouse and it is demonstrated that InterCellDB‐inferred cell–cell interactions and ligand–receptor pairs are experimentally valid.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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InterCellDB: A User‐Defined Database for Inferring Intercellular Networks ; day:02 ; month:06 ; year:2022 ; extent:11
Advanced science ; (02.06.2022) (gesamt 11)
- Urheber
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Jin, Ziyang
Zhang, Xiaotao
Dai, Xuejiao
Huang, Jinyan
Hu, Xiaoming
Zhang, Jianmin
Shi, Ligen
- DOI
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10.1002/advs.202200045
- URN
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urn:nbn:de:101:1-2022060215530762197107
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:31 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Jin, Ziyang
- Zhang, Xiaotao
- Dai, Xuejiao
- Huang, Jinyan
- Hu, Xiaoming
- Zhang, Jianmin
- Shi, Ligen
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