Non‐Directed C−H Arylation of Anisole Derivatives via Pd/S,O‐Ligand Catalysis

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Abstract: Non‐directed C−H arylation is one of the most efficient methods to synthesize biaryl compounds without the need of the prefuctionalization of starting materials, or the installment and removal of directing groups on the substrate. A direct C−H arylation of simple arenes as limiting reactants remains a challenge. Here we disclose a non‐directed C−H arylation of anisole derivatives as limiting reagents with aryl iodides under mild reaction conditions. The arylated products are obtained in synthetically useful yields and the arylation of bioactive molecules is also demonstrated. Key to the success of this methodology is the use of a one‐step synthesized S,O‐ligand.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Non‐Directed C−H Arylation of Anisole Derivatives via Pd/S,O‐Ligand Catalysis ; day:13 ; month:03 ; year:2024 ; extent:7
Angewandte Chemie ; (13.03.2024) (gesamt 7)

Creator: Deng, Ke‐Zuan
Sukowski, Verena
Fernández‐Ibáñez, M. Ángeles

DOI: 10.1002/ange.202400689

URN: urn:nbn:de:101:1-2024031413034077422762

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 14.08.2025, 10:51 AM CEST

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Associated

Deng, Ke‐Zuan
Sukowski, Verena
Fernández‐Ibáñez, M. Ángeles

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