FUT8: from biochemistry to synthesis of core-fucosylated N -glycans
Abstract: Glycosylation is a major posttranslational modification of proteins. Modification in structure on N-glycans leads to many diseases. One of such modifications is core α-1,6 fucosylation, which is only found in eukaryotes. For this reason, lots of research has been done on approaches to synthesize core-fucosylated N-glycans both chemically and enzymatically, in order to have well defined structures that can be used as probes for glycan analysis and identifying functions of glycan-binding proteins. This review will focus on FUT8, the enzyme responsible for core fucosylation in mammals and the strategies that have been developed for the synthesis of core fucosylated N-glycans have been synthesized so far.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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FUT8: from biochemistry to synthesis of core-fucosylated N -glycans ; volume:89 ; number:7 ; year:2017 ; pages:911-920 ; extent:10
Pure and applied chemistry ; 89, Heft 7 (2017), 911-920 (gesamt 10)
- Urheber
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Calderon, Angie D.
Li, Lei
Wang, Peng G.
- DOI
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10.1515/pac-2016-0923
- URN
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urn:nbn:de:101:1-2024030613214746216018
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 10:50 MESZ
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Beteiligte
- Calderon, Angie D.
- Li, Lei
- Wang, Peng G.
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