Transaminase‐Catalyzed Racemization with Potential for Dynamic Kinetic Resolutions
Abstract: Dynamic kinetic resolution (DKR) reactions in which a stereoselective enzyme and a racemization step are coupled in one pot would represent powerful tools for the production of enantiopure amines through enantioconvergence of racemates. The exploitation of DKR strategies is currently hampered by the lack of effective, enzyme‐compatible and scalable racemization strategies for amines. In the present work, the proof of concept of a fully biocatalytic method for amine racemization is presented. Both enantiomers of the model compound 1‐methyl‐3‐phenylpropylamine could be racemized in water and at room temperature using a couple of wild‐type, non‐proprietary, enantiocomplementary amine transaminases and a minimum amount of pyruvate/alanine as a co‐substrate couple. The biocatalytic simultaneous parallel cascade reaction presented here poses itself as a customizable amine racemization system with potential for the chemical industry in competition with traditional transition‐metal catalysis.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Transaminase‐Catalyzed Racemization with Potential for Dynamic Kinetic Resolutions ; volume:10 ; number:21 ; year:2018 ; pages:5012-5018 ; extent:7
ChemCatChem ; 10, Heft 21 (2018), 5012-5018 (gesamt 7)
- Creator
- DOI
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10.1002/cctc.201801049
- URN
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urn:nbn:de:101:1-2022082608305069362380
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:24 AM CEST
Data provider
This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Ruggieri, Federica
- van Langen, Luuk M.
- Logan, Derek T.
- Walse, Björn
- Berglund, Per
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Ruthenium-Catalyzed Dynamic Kinetic Resolution of Cycloketones
Lewis Base-Catalyzed Dynamic Kinetic Resolution of Azole Esters
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