Transaminase‐Catalyzed Racemization with Potential for Dynamic Kinetic Resolutions
Abstract: Dynamic kinetic resolution (DKR) reactions in which a stereoselective enzyme and a racemization step are coupled in one pot would represent powerful tools for the production of enantiopure amines through enantioconvergence of racemates. The exploitation of DKR strategies is currently hampered by the lack of effective, enzyme‐compatible and scalable racemization strategies for amines. In the present work, the proof of concept of a fully biocatalytic method for amine racemization is presented. Both enantiomers of the model compound 1‐methyl‐3‐phenylpropylamine could be racemized in water and at room temperature using a couple of wild‐type, non‐proprietary, enantiocomplementary amine transaminases and a minimum amount of pyruvate/alanine as a co‐substrate couple. The biocatalytic simultaneous parallel cascade reaction presented here poses itself as a customizable amine racemization system with potential for the chemical industry in competition with traditional transition‐metal catalysis.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
Transaminase‐Catalyzed Racemization with Potential for Dynamic Kinetic Resolutions ; volume:10 ; number:21 ; year:2018 ; pages:5012-5018 ; extent:7
ChemCatChem ; 10, Heft 21 (2018), 5012-5018 (gesamt 7)
- Urheber
- DOI
-
10.1002/cctc.201801049
- URN
-
urn:nbn:de:101:1-2022082608305069362380
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
15.08.2025, 07:24 MESZ
Datenpartner
Dieses Objekt wird bereitgestellt von:
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Ruggieri, Federica
- van Langen, Luuk M.
- Logan, Derek T.
- Walse, Björn
- Berglund, Per
Ähnliche Objekte (12)
Recombinant l‐Amino Acid Oxidase with Broad Substrate Spectrum for Co‐substrate Recycling in (S)‐Selective Transaminase‐Catalyzed Kinetic Resolutions
Recombinant l ‐Amino Acid Oxidase with Broad Substrate Spectrum for Co‐substrate Recycling in (S)‐Selective Transaminase‐Catalyzed Kinetic Resolutions
Ruthenium-Catalyzed Dynamic Kinetic Resolution of Cycloketones
Lewis Base-Catalyzed Dynamic Kinetic Resolution of Azole Esters
Atroposelective Synthesis of 2‐(Quinolin‐8‐yl) benzyl Alcohols by Biocatalytic Dynamic Kinetic Resolutions
Tetrapeptide-Catalyzed Dynamic Kinetic Resolution Grants Access to Helically Chiral Loratadine Analogues
Continuous Preparative Application of Amine Transaminase‐Catalyzed Reactions with Integrated Crystallization
Dynamic Kinetic Resolution of 2‐Hydroxybiaryl Atropisomers via Lipase‐Catalyzed Enantioselective O ‐Acylation
Dynamic Kinetic Resolution (DKR) and Dynamic Kinetic Asymmetric Transformations (DYKAT)
N-Heterocyclic carbene-catalyzed enantioselective synthesis of planar-chiral cyclophanes via dynamic kinetic resolution
Dynamic Kinetic Resolution Strategy for the Asymmetric Nickel-Catalyzed Capture of Transient Cyclic Allenes
Enantioconvergent synthesis of axially chiral amides enabled by Pd-catalyzed dynamic kinetic asymmetric aminocarbonylation
Recombinant l‐Amino Acid Oxidase with Broad Substrate Spectrum for Co‐substrate Recycling in (S)‐Selective Transaminase‐Catalyzed Kinetic Resolutions
Recombinant l ‐Amino Acid Oxidase with Broad Substrate Spectrum for Co‐substrate Recycling in (S)‐Selective Transaminase‐Catalyzed Kinetic Resolutions
Ruthenium-Catalyzed Dynamic Kinetic Resolution of Cycloketones
Lewis Base-Catalyzed Dynamic Kinetic Resolution of Azole Esters
Atroposelective Synthesis of 2‐(Quinolin‐8‐yl) benzyl Alcohols by Biocatalytic Dynamic Kinetic Resolutions
Tetrapeptide-Catalyzed Dynamic Kinetic Resolution Grants Access to Helically Chiral Loratadine Analogues
Continuous Preparative Application of Amine Transaminase‐Catalyzed Reactions with Integrated Crystallization
Dynamic Kinetic Resolution of 2‐Hydroxybiaryl Atropisomers via Lipase‐Catalyzed Enantioselective O ‐Acylation
Dynamic Kinetic Resolution (DKR) and Dynamic Kinetic Asymmetric Transformations (DYKAT)
N-Heterocyclic carbene-catalyzed enantioselective synthesis of planar-chiral cyclophanes via dynamic kinetic resolution
Dynamic Kinetic Resolution Strategy for the Asymmetric Nickel-Catalyzed Capture of Transient Cyclic Allenes
Enantioconvergent synthesis of axially chiral amides enabled by Pd-catalyzed dynamic kinetic asymmetric aminocarbonylation
Recombinant l‐Amino Acid Oxidase with Broad Substrate Spectrum for Co‐substrate Recycling in (S)‐Selective Transaminase‐Catalyzed Kinetic Resolutions
Recombinant l ‐Amino Acid Oxidase with Broad Substrate Spectrum for Co‐substrate Recycling in (S)‐Selective Transaminase‐Catalyzed Kinetic Resolutions
Ruthenium-Catalyzed Dynamic Kinetic Resolution of Cycloketones
Lewis Base-Catalyzed Dynamic Kinetic Resolution of Azole Esters
Atroposelective Synthesis of 2‐(Quinolin‐8‐yl) benzyl Alcohols by Biocatalytic Dynamic Kinetic Resolutions
Tetrapeptide-Catalyzed Dynamic Kinetic Resolution Grants Access to Helically Chiral Loratadine Analogues
Continuous Preparative Application of Amine Transaminase‐Catalyzed Reactions with Integrated Crystallization
Dynamic Kinetic Resolution of 2‐Hydroxybiaryl Atropisomers via Lipase‐Catalyzed Enantioselective O ‐Acylation
Dynamic Kinetic Resolution (DKR) and Dynamic Kinetic Asymmetric Transformations (DYKAT)
N-Heterocyclic carbene-catalyzed enantioselective synthesis of planar-chiral cyclophanes via dynamic kinetic resolution
Dynamic Kinetic Resolution Strategy for the Asymmetric Nickel-Catalyzed Capture of Transient Cyclic Allenes