Beyond Dimerization: Harnessing Tetrameric Coiled‐Coils for Nanostructure Assembly
Abstract: Versatile DNA and polypeptide‐based structures have been designed based on complementary modules. However, polypeptides can also form higher oligomeric states. We investigated the introduction of tetrameric modules as a substitute for coiled‐coil dimerization units used in previous modular nanostructures. Tetramerizing helical bundles can run in parallel or antiparallel orientation, expanding the number of topological solutions for modular nanostructures. Furthermore, this strategy facilitates the construction of nanostructures from two identical polypeptide chains. Importantly, tetrameric modules substantially stabilized protein nanostructures against air–water interface denaturation, enabling the determination of the first cryo‐electron microscopy three‐dimensional structure of a coiled‐coil‐based nanostructure, confirming the designed agreement of the modules forming a tetrahedral cage.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Beyond Dimerization: Harnessing Tetrameric Coiled‐Coils for Nanostructure Assembly ; day:19 ; month:12 ; year:2024 ; extent:9
Angewandte Chemie ; (19.12.2024) (gesamt 9)
- Creator
-
Vidmar, Sara
Šmidlehner, Tamara
Aupič, Jana
Strmšek, Žiga
Ljubetič, Ajasja
Xiao, Fei
Hu, Guang
Liu, Chuan
Beck, Florian
Erdmann, Philipp S.
Jerala, Roman
- DOI
-
10.1002/ange.202422075
- URN
-
urn:nbn:de:101:1-2412201326355.033397069504
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:29 AM CEST
Data provider
This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Vidmar, Sara
- Šmidlehner, Tamara
- Aupič, Jana
- Strmšek, Žiga
- Ljubetič, Ajasja
- Xiao, Fei
- Hu, Guang
- Liu, Chuan
- Beck, Florian
- Erdmann, Philipp S.
- Jerala, Roman
Other Objects (12)
Beyond Dimerization: Harnessing Tetrameric Coiled‐Coils for Nanostructure Assembly
Experimentelle Untersuchungen zur Einleitung eines Drallstroms im Teillastbetrieb eines radialen Kreiselpumpenlaufrades
ICT and productivity growth within value chains
ICT and Productivity Growth Within Value Chains
Factors related to health-related quality of life among Chinese psychiatrists: occupational stress and psychological capital
Coiled coils as mechanical building blocks
The science behind the development and performance of reduced ignition propensity cigarettes
Nonlinear Dynamic Analysis of high speed multiple units Gear Transmission System with Wear Fault
Early outcomes of the arthroscopic Latarjet procedure in a series of 37 patients with shoulder instability
Bacillus subtilis: a universal cell factory for industry, agriculture, biomaterials and medicine
The Structure and Evolution of Non-canonical Coiled coils
Coiled coils as possible models of protein structure evolution
Beyond Dimerization: Harnessing Tetrameric Coiled‐Coils for Nanostructure Assembly
Experimentelle Untersuchungen zur Einleitung eines Drallstroms im Teillastbetrieb eines radialen Kreiselpumpenlaufrades
ICT and productivity growth within value chains
ICT and Productivity Growth Within Value Chains
Factors related to health-related quality of life among Chinese psychiatrists: occupational stress and psychological capital
Coiled coils as mechanical building blocks
The science behind the development and performance of reduced ignition propensity cigarettes
Nonlinear Dynamic Analysis of high speed multiple units Gear Transmission System with Wear Fault
Early outcomes of the arthroscopic Latarjet procedure in a series of 37 patients with shoulder instability
Bacillus subtilis: a universal cell factory for industry, agriculture, biomaterials and medicine
The Structure and Evolution of Non-canonical Coiled coils
Coiled coils as possible models of protein structure evolution
Beyond Dimerization: Harnessing Tetrameric Coiled‐Coils for Nanostructure Assembly
Experimentelle Untersuchungen zur Einleitung eines Drallstroms im Teillastbetrieb eines radialen Kreiselpumpenlaufrades
ICT and productivity growth within value chains
ICT and Productivity Growth Within Value Chains
Factors related to health-related quality of life among Chinese psychiatrists: occupational stress and psychological capital
Coiled coils as mechanical building blocks
The science behind the development and performance of reduced ignition propensity cigarettes
Nonlinear Dynamic Analysis of high speed multiple units Gear Transmission System with Wear Fault
Early outcomes of the arthroscopic Latarjet procedure in a series of 37 patients with shoulder instability
Bacillus subtilis: a universal cell factory for industry, agriculture, biomaterials and medicine
The Structure and Evolution of Non-canonical Coiled coils