The fitness cost and benefit of phase‐separated protein deposits
Abstract: Phase separation of soluble proteins into insoluble deposits is associated with numerous diseases. However, protein deposits can also function as membrane‐less compartments for many cellular processes. What are the fitness costs and benefits of forming such deposits in different conditions? Using a model protein that phase‐separates into deposits, we distinguish and quantify the fitness contribution due to the loss or gain of protein function and deposit formation in yeast. The environmental condition and the cellular demand for the protein function emerge as key determinants of fitness. Protein deposit formation can influence cell‐to‐cell variation in free protein abundance between individuals of a cell population (i.e., gene expression noise). This results in variable manifestation of protein function and a continuous range of phenotypes in a cell population, favoring survival of some individuals in certain environments. Thus, protein deposit formation by phase separation might be a mechanism to sense protein concentration in cells and to generate phenotypic variability. The selectable phenotypic variability, previously described for prions, could be a general property of proteins that can form phase‐separated assemblies and may influence cell fitness.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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The fitness cost and benefit of phase‐separated protein deposits ; volume:15 ; number:4 ; year:2019 ; extent:20
Molecular systems biology ; 15, Heft 4 (2019) (gesamt 20)
- Creator
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Sanchez de Groot, Natalia
Torrent Burgas, Marc
Ravarani, Charles NJ
Trusina, Ala
Ventura, Salvador
Babu, M. Madan
- DOI
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10.15252/msb.20178075
- URN
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urn:nbn:de:101:1-2022073007343602176481
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
- 15.08.2025, 7:39 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Sanchez de Groot, Natalia
- Torrent Burgas, Marc
- Ravarani, Charles NJ
- Trusina, Ala
- Ventura, Salvador
- Babu, M. Madan
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