Homocysteine and methylmalonic acid in Phenylketonuria patients
Abstract: Hyperhomocysteinemia and vitamin B12 deficiency have been reported in patients with phenylketonuria. In this study, total homocysteine (tHcy) and methylmalonic acid (MMA) levels were analyzed in samples from 25 phenylketonuria (PKU) patients. Comparisons were made between pre- and post-treatment values (n= 3); on treatment values, between periods with high and normal/low phenylalanine (Phe) levels (n= 20); and in women before, during and after pregnancy (n= 3). THcy levels decreased after treating PKU with metabolic formula (p=0.014). Except for a pregnant woman before pregnancy, none of the patients had tHcy values above the normal range. In fact, tHcy was < 5 μmol/L in 34% of the samples. We observed a decrease in Phe, tHcy, and tyrosine levels during pregnancy. MMA levels did not differ significantly, with values remaining in the normal range. These data indicate that there was no B12 deficiency in patients who adhere to the diet. In conclusion, in PKU patients treated with metabolic formula, tHcy is frequently not elevated, remaining even in the lower normal range in some patients. Thus, clinical follow-up and adherence to dietary treatment are crucial to prevent B12 deficiency
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Notes
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Genetics and molecular biology. - 46, 3 (suppl 1) (2023) , e20230103, ISSN: 1678-4685
- Event
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Veröffentlichung
- (where)
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Freiburg
- (who)
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Universität
- (when)
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2024
- Creator
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Hoss, Giovana Regina Weber
Sperb-Ludwig, Fernanda
Tonon, Tássia
Poloni, Soraia
Behringer, Sidney
Blom, Henk J.
Maillot, François
Schwartz, Ida Vanessa
- DOI
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10.1590/1678-4685-gmb-2023-0103
- URN
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urn:nbn:de:bsz:25-freidok-2488750
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:54 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Hoss, Giovana Regina Weber
- Sperb-Ludwig, Fernanda
- Tonon, Tássia
- Poloni, Soraia
- Behringer, Sidney
- Blom, Henk J.
- Maillot, François
- Schwartz, Ida Vanessa
- Universität
Time of origin
- 2024