Allogeneic stem cell transplantation for myelodysplastic syndrome patients with a 5q deletion

Abstract: The deletion (5q) karyotype (del [5q]) in patients with myelodysplastic syndrome (MDS) is the most common karyotypic abnormality in de novo MDS. An increased number of blasts and additional karyotypic abnormalities (del [5q]+) are associated with a poor outcome. We analyzed the outcome of allogeneic hematopoietic cell transplants (HCT) in patients suffering from MDS with only del (5q) or del (5q)+ . A total of 162 patients, of median age 54 years (range, 9 to 73), having MDS and del (5q) abnormalities received HCT from identical siblings (n = 87) or unrelated donors (n = 75). The cumulative incidence of nonrelapse mortality and relapse incidence at 4 years was 29% (95% CI, 22 to 36) and 46% (95% CI, 38 to 54), whereas the estimated 4 year survival, relapse-free and overall, was 25% (95% CI, 18 to 33) and 30% (95% CI, 23 to 38), respectively. In a multivariate analysis patients with del (5q) and a blast excess displayed poorer survival (hazard ratio, 2.38; 95% CI, 1.44 to 3.93; P < .001), whereas female recipient sex resulted in improved survival (hazard ratio, .61; 95% CI, .41 to .90; P = .01). We conclude that allogeneic HCT can cure a subset of patients with MDS and a del (5q) abnormality

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch
• Notes: Biology of blood and marrow transplantation. - 24, 3 (2018) , 507-513, ISSN: 1523-6536

Contributors, Places and Time

• Event: Veröffentlichung
• (where): Freiburg
• (who): Universität
• (when): 2019
• Creator: Garderet, Laurent ; Ziagkos, Dimitris ; Biezen, Anja van ; Iacobelli, Simona ; Finke, Jürgen ; Maertens, Johan ; Volin, Liisa ; Ljungman, Per ; Chevallier, Patrice ; Passweg, Jakob R. ; Schaap, Nicolaas ; Beelen, Dietrich W. ; Nagler, Arnon ; Blaise, Didier ; Poiré, Xavier ; Yakoub-Agha, Ibrahim ; Lenhoff, Stig ; Craddock, Charles ; Schots, Rik ; Rambaldi, Alessandro ; Sanz, Jaime ; Jindra, Pavel ; Mufti, Ghulam ; Robin, Marie ; Kröger, Nicolaus

Further information

• DOI: 10.1016/j.bbmt.2017.11.017
• URN: urn:nbn:de:bsz:25-freidok-1424637
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 25.03.2025, 1:53 PM CET