Design, Synthesis and Biological Evaluation of Novel Gypsogenin Derivatives as Potential Anticancer and Antimicrobial Agents
Abstract: Natural compounds are important sources for the treatment of chronic disorders such as cancer and microbial infectious disorders. In this research, Gypsogenin and its derivatives (2 a–2 f) have been tested against different cancer cell lines (MCF‐7, HeLa, Jurkat and K562 cell lines) and further analyzed for cell proliferation, cell death type, and for act of the mechanism. Cell proliferation was determined by the MTT method and cell death types were analyzed with HO/PI staining. Fibroblast Growth Factor 1 (FGF‐1), Interleukin 1 (IL‐1), Interleukin 6 (IL‐6), and Tumor Necrosis Factor Alpha (TNF‐α), key players in breast cancer development and progression, were determined by Elisa kits. Results showed that compound 2 e inhibited the MCF‐7 cell line proliferation with an IC50 value of 0.66±0.17 μM with 93.38 % apoptosis rate. Compound 2 e also decreased FGF‐1, IL‐1, IL‐6, and TNF‐α levels. Molecular docking studies performed in the binding site of FGFR‐1 indicated that compound 2 e formed key hydrogen bonding with Arg627 and Asn568. Besides, compounds 2 a–2 f were evaluated for their antimicrobial activities against gram‐negative and gram‐positive bacteria and C. albicans via the microdilution method. Overall, compound 2 e stands out as a potential anticancer agent for future studies.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Design, Synthesis and Biological Evaluation of Novel Gypsogenin Derivatives as Potential Anticancer and Antimicrobial Agents ; day:12 ; month:05 ; year:2024 ; extent:10
Chemistry & biodiversity ; (12.05.2024) (gesamt 10)
- Creator
-
Emirdağ, Safiye
Ulusoy, Nafia Gökçe
Aksel, Mehran
- DOI
-
10.1002/cbdv.202400471
- URN
-
urn:nbn:de:101:1-2405121409154.103711579057
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
14.08.2025, 10:56 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Emirdağ, Safiye
- Ulusoy, Nafia Gökçe
- Aksel, Mehran
Other Objects (12)
Thiadiazole derivatives as anticancer agents
Synthesis and Biological Evaluation of Benzodioxole Derivatives as Potential Anticancer and Antioxidant agents
Design, synthesis, and biological evaluation of phenyl-isoxazole-carboxamide derivatives as anticancer agents
Synthesis, biological evaluation, and computational studies of some novel quinazoline derivatives as anticancer agents
Recent updates on thienopyrimidine derivatives as anticancer agents
Synthesis and biological evaluation of new 3-(4-substituted phenyl) aminoquinoxaline derivatives as anticancer agents
Design, synthesis and biological potential of heterocyclic benzoxazole scaffolds as promising antimicrobial and anticancer agents
Derivatives of nitrogen mustard anticancer agents with improved cytotoxicity
Synthesis, biological evaluation and in-silico ADME studies of novel series of thiazolidin-2,4-dione derivatives as antimicrobial, antioxidant and anticancer agents
Green, facile synthesis and evaluation of unsymmetrical carbamide derivatives as antimicrobial and anticancer agents with mechanistic insights
Design, synthesis, molecular docking and biological evaluation of new carbazole derivatives as anticancer, and antioxidant agents
Synthesis and biological evaluation of new 1,3,4-thiadiazole derivatives as potent antimicrobial agents
Thiadiazole derivatives as anticancer agents
Synthesis and Biological Evaluation of Benzodioxole Derivatives as Potential Anticancer and Antioxidant agents
Design, synthesis, and biological evaluation of phenyl-isoxazole-carboxamide derivatives as anticancer agents
Synthesis, biological evaluation, and computational studies of some novel quinazoline derivatives as anticancer agents
Recent updates on thienopyrimidine derivatives as anticancer agents
Synthesis and biological evaluation of new 3-(4-substituted phenyl) aminoquinoxaline derivatives as anticancer agents
Design, synthesis and biological potential of heterocyclic benzoxazole scaffolds as promising antimicrobial and anticancer agents
Derivatives of nitrogen mustard anticancer agents with improved cytotoxicity
Synthesis, biological evaluation and in-silico ADME studies of novel series of thiazolidin-2,4-dione derivatives as antimicrobial, antioxidant and anticancer agents
Green, facile synthesis and evaluation of unsymmetrical carbamide derivatives as antimicrobial and anticancer agents with mechanistic insights
Design, synthesis, molecular docking and biological evaluation of new carbazole derivatives as anticancer, and antioxidant agents
Synthesis and biological evaluation of new 1,3,4-thiadiazole derivatives as potent antimicrobial agents
Thiadiazole derivatives as anticancer agents
Synthesis and Biological Evaluation of Benzodioxole Derivatives as Potential Anticancer and Antioxidant agents
Design, synthesis, and biological evaluation of phenyl-isoxazole-carboxamide derivatives as anticancer agents
Synthesis, biological evaluation, and computational studies of some novel quinazoline derivatives as anticancer agents
Recent updates on thienopyrimidine derivatives as anticancer agents
Synthesis and biological evaluation of new 3-(4-substituted phenyl) aminoquinoxaline derivatives as anticancer agents
Design, synthesis and biological potential of heterocyclic benzoxazole scaffolds as promising antimicrobial and anticancer agents
Derivatives of nitrogen mustard anticancer agents with improved cytotoxicity
Synthesis, biological evaluation and in-silico ADME studies of novel series of thiazolidin-2,4-dione derivatives as antimicrobial, antioxidant and anticancer agents
Green, facile synthesis and evaluation of unsymmetrical carbamide derivatives as antimicrobial and anticancer agents with mechanistic insights
Design, synthesis, molecular docking and biological evaluation of new carbazole derivatives as anticancer, and antioxidant agents