Multifunctional Fiber‐Based Optoacoustic Emitter as a Bidirectional Brain Interface
Abstract: A bidirectional brain interface with both “write” and “read” functions can be an important tool for fundamental studies and potential clinical treatments for neurological diseases. Herein, a miniaturized multifunctional fiber‐based optoacoustic emitter (mFOE) is reported thatintegrates simultaneous optoacoustic stimulation for “write” and electrophysiology recording of neural circuits for “read”. Because of the intrinsic ability of neurons to respond to acoustic wave, there is no requirement of the viral transfection. The orthogonality between optoacoustic waves and electrical field provides a solution to avoid the interference between electrical stimulation and recording. The stimulation function of the mFOE is first validated in cultured ratcortical neurons using calcium imaging. In vivo application of mFOE for successful simultaneous optoacoustic stimulation and electrical recording of brain activities is confirmed in mouse hippocampus in both acute and chronical applications up to 1 month. Minor brain tissue damage is confirmed after these applications. The capability of simultaneous neural stimulation and recording enabled by mFOE opens up new possibilities for the investigation of neural circuits and brings new insights into the study of ultrasound neurostimulation.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Multifunctional Fiber‐Based Optoacoustic Emitter as a Bidirectional Brain Interface ; day:31 ; month:07 ; year:2023 ; extent:13
Advanced healthcare materials ; (31.07.2023) (gesamt 13)
- Urheber
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Zheng, Nan
Jiang, Ying
Jiang, Shan
Kim, Jongwoon
Chen, Guo
Li, Yueming
Cheng, Ji‐Xin
Jia, Xiaoting
Yang, Chen
- DOI
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10.1002/adhm.202300430
- URN
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urn:nbn:de:101:1-2023080115053418952284
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 10:53 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Zheng, Nan
- Jiang, Ying
- Jiang, Shan
- Kim, Jongwoon
- Chen, Guo
- Li, Yueming
- Cheng, Ji‐Xin
- Jia, Xiaoting
- Yang, Chen
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