Navigating Challenges in Monitoring Chronic Myeloid Leukemia with Multiple BCR-ABL1 Transcripts
Quantitative PCR-based strategies are typically effective for monitoring BCR-ABL1 transcript levels in chronic myeloid leukemia (CML). Additionally, some patients treated with tyrosine kinase inhibitors can experience long-term treatment-free remission after discontinuation of the inhibitor. However, this outcome hinges on effectively monitoring the patient’s response to therapy. We present a patient with CML and multiple BCR-ABL1 transcripts, including a rare isoform that lacks qPCR standardization. We describe unexpected discrepancies in transcript quantification, further having an impact on clinical decision-making regarding duration of treatment. To better inform clinical practice, we suggest monitoring patients at the same testing facility to better track transcript trend.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Navigating Challenges in Monitoring Chronic Myeloid Leukemia with Multiple BCR-ABL1 Transcripts ; volume:14 ; number:3 ; year:2021 ; pages:1707-1711 ; extent:5
Case reports in oncology ; 14, Heft 3 (2021), 1707-1711 (gesamt 5)
- Creator
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Smith, Brittany M.
Brewer, Diana
Druker, Brian J.
Braun, Theodore P.
- DOI
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10.1159/000520400
- URN
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urn:nbn:de:101:1-2022011223393933873397
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:33 AM CEST
Data provider
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Associated
- Smith, Brittany M.
- Brewer, Diana
- Druker, Brian J.
- Braun, Theodore P.
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