Endoscopic Retrograde Appendicitis Therapy for Acute Appendicitis: A Systematic Review and Meta-Analysis

Background and study aim: Endoscopic Retrograde Appendicitis Therapy (ERAT) is an endoscopic procedure for management of patients with acute appendicitis (AA). In addition to being minimally invasive, it has added advantage of preservation of appendix and simultaneous inspection of colon. We performed a systematic review and meta-analysis on ERAT in patients with AA. Patients and methods: We conducted a comprehensive search of multiple electronic databases (from inception through Jan 2022) to identify the studies reporting ERAT in AA. The primary outcome was to evaluate the overall clinical and technical success of ERAT. The secondary outcome was to study the total and individual adverse events. The meta-analysis was performed using Der Simonian and Laird random effect model. Results 7 studies reporting on 298 patients were included. Majority of the patient population were males (55.3%), with mean age of 31±12.39 years. The pooled technical success rate was 99.36% (95% CI 97.61-100, I2=0) and the pooled clinical success rate was 99.29% (95% CI 97.48-100, I2=0). The pooled adverse event rate was 0.19 % (95% CI 0-1.55, I2=0). The most common adverse event was perforation with 0.19 % (95% CI 0-1.55, I2=0). Recurrence rate was 6.01 % (95% CI 2.9-9.93, I2=20.10). Average length of procedure was 41.1±7.16 min. Low heterogeneity was noted in in our meta-analysis. Conclusion: ERAT is a safe procedure with high clinical and technical success in patients with acute appendicitis. Further randomized controlled trials should be performed to assess utility of ERAT in acute appendicitis as compared to laparoscopic appendectomy.

Show object

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Endoscopic Retrograde Appendicitis Therapy for Acute Appendicitis: A Systematic Review and Meta-Analysis ; day:07 ; month:04 ; year:2022 ; Endoscopy International Open ; (07.04.2022)

Contributors, Places and Time

• Contributor: Dhindsa, Banreet S. ; Naga, Yassin ; Praus, Alexander ; Saghir, Syed Mohsin ; Mashiana, Harmeet Singh ; Ramai, Daryl ; Chandan, Saurabh ; Sayles, Harlan ; Dhaliwal, Amaninder ; Bhat, Ishfaq ; Singh, Shailender ; Adler, Douglas G.

Further information

• DOI: 10.1055/a-1819-8231
• URN: urn:nbn:de:101:1-2022052610261625180542
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.