Paintable Decellularized‐ECM Hydrogel for Preventing Cardiac Tissue Damage
Abstract: The tissue‐specific heart decellularized extracellular matrix (hdECM) demonstrates a variety of therapeutic advantages, including fibrosis reduction and angiogenesis. Consequently, recent research for myocardial infarction (MI) therapy has utilized hdECM with various delivery techniques, such as injection or patch implantation. In this study, a novel approach for hdECM delivery using a wet adhesive paintable hydrogel is proposed. The hdECM‐containing paintable hydrogel (pdHA_t) is simply applied, with no theoretical limit to the size or shape, making it highly beneficial for scale‐up. Additionally, pdHA_t exhibits robust adhesion to the epicardium, with a minimal swelling ratio and sufficient adhesion strength for MI treatment when applied to the rat MI model. Moreover, the adhesiveness of pdHA_t can be easily washed off to prevent undesired adhesion with nearby organs, such as the rib cages and lungs, which can result in stenosis. During the 28 days of in vivo analysis, the pdHA_t not only facilitates functional regeneration by reducing ventricular wall thinning but also promotes neo‐vascularization in the MI region. In conclusion, the pdHA_t presents a promising strategy for MI treatment and cardiac tissue regeneration, offering the potential for improved patient outcomes and enhanced cardiac function post‐MI.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Paintable Decellularized‐ECM Hydrogel for Preventing Cardiac Tissue Damage ; day:19 ; month:03 ; year:2024 ; extent:16
Advanced science ; (19.03.2024) (gesamt 16)
- Creator
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Lee, Jaewoo
Lee, Seul‐Gi
Kim, Beom‐seok
Park, Shinhye
Sundaram, M. Nivedhitha
Kim, Byung‐gee
Kim, C‐Yoon
Hwang, Nathaniel S.
- DOI
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10.1002/advs.202307353
- URN
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urn:nbn:de:101:1-2024032014390452296981
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:58 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Lee, Jaewoo
- Lee, Seul‐Gi
- Kim, Beom‐seok
- Park, Shinhye
- Sundaram, M. Nivedhitha
- Kim, Byung‐gee
- Kim, C‐Yoon
- Hwang, Nathaniel S.
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